Human EGFR (ErbB1) [T790M, L858R], GST Tag Recombinant Protein

Human EGFR (ErbB1) [T790M, L858R], GST Tag Recombinant Protein

Product Code	Brand	Description
10479793	Invitrogen PV4879	10μg

Description

The epidermal growth factor receptor is a receptor tyrosine kinases that signals in response to various growth factors. Overexpression has been linked to numerous types of cancer and EGFR is the target of both biological and small molecular therapeutics. The double T790M L858R mutant of EGFR displays resistance to Erlotinib (Tarceva) and sensitivity to HKI-272 and rapamycin combination therapy.

Specifications

• Accession Number: NP_005219.2; T790M L858R
• Molecular Weight (g/mol): 90.6 kDa
• KinaseFamily: EGF Receptor (ErbB) Kinase Family
• Recombinant: Recombinant
• Content And Storage: Storage Buffer: 50 mM Tris pH 7.5, 150 mM NaCl, 0.5 mM EDTA, 0.02% Polysorbate 20, 2 mM DTT, 50% glycerol
  Store at -80°C. At first use, aliquot and store at -80°C to avoid multiple freeze-thaws.
• Shipping Condition: Dry Ice

• For Use With (Application): Kinase Assay
• Gene Alias: EGFR (ErbB1) T790M L858R
• Species: Human
• Protein Tag: GST Tag
• Kinase Group: Tyrosine Kinases
• Expression System: Baculovirus