Human EGFR (ErbB1) [T790M, L858R], GST Tag Recombinant Protein

Human EGFR (ErbB1) [T790M, L858R], GST Tag Recombinant Protein

Brand:  Invitrogen PV4879

Product Code. 10479793

Description

The epidermal growth factor receptor is a receptor tyrosine kinases that signals in response to various growth factors. Overexpression has been linked to numerous types of cancer and EGFR is the target of both biological and small molecular therapeutics. The double T790M L858R mutant of EGFR displays resistance to Erlotinib (Tarceva) and sensitivity to HKI-272 and rapamycin combination therapy.

Specifications

• Accession Number: NP_005219.2; T790M L858R
• Gene ID (Entrez): 1956
• Quantity: 10 μg
• KinaseFamily: EGF Receptor (ErbB) Kinase Family
• Species: Human
• Protein Tag: GST Tag
• Assay Entry: Biochemical binding/kinetic
• Shipping Condition: Dry Ice
• Target Entry: EGFR T790M L858R
• Expression System: Baculovirus
• Protein Form: Recombinant, Catalytic Domain, Cytoplasmic, Mutant
• Protein Subtype: Receptor Tyrosine Kinases

• For Use With (Application): Kinase Assay
• Molecular Weight (g/mol): 90.6 kDa
• Gene Alias: EGFR (ErbB1) T790M L858R
• Protein Length: aa 668-1210; T790M, L858R
• Recombinant: Recombinant
• Content And Storage: Storage Buffer: 50 mM Tris pH 7.5, 150 mM NaCl, 0.5 mM EDTA, 0.02% Polysorbate 20, 2 mM DTT, 50% glycerol
  Store at -80°C. At first use, aliquot and store at -80°C to avoid multiple freeze-thaws.
• Kinase Group: Tyrosine Kinases
• System Compatibility: Z'-LYTE™
• Target Gene: Epidermal growth factor receptor
• Protein Family: Kinases & Inhibitors
• Form: Liquid
• Research Category: Oncology, Signal Transduction