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Invitrogen™ eBioscience™ Annexin V Apoptosis Detection Kits

eBioscience and Annexin V Apoptosis Detection kits use dye-conjugated annexin V to distinguish live and apoptotic cells.

£102.00 - £359.00


Products 18
Product Code Brand Conjugate Excitation/Emission Price Quantity & Availability  
Product Code Brand Conjugate Excitation/Emission Price Quantity & Availability  
12770170
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Invitrogen™
88-8005-74
FITC, Propidium Iodide 488, 535/520, 617
£320.00
Each
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Estimated Shipment: 15-06-2022
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15561187
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Invitrogen™
88-8006-72
eFluor 450, 7-AAD 405, 546/450, 647
£144.00
50 tests
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Estimated Shipment: 26-05-2022
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15571187
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Invitrogen™
88-8006-74
eFluor 450, 7-AAD 405, 546/450, 647
£256.00
200 tests
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Estimated Shipment: 08-06-2022
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12780170
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Invitrogen™
88-8007-74
APC, Propidium Iodide 650, 535/660, 617
£349.00
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15591187
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Invitrogen™
88-8008-72
PCP-eFluor 710
£165.00
50 tests
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Estimated Shipment: 30-05-2022
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15413392
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Invitrogen™
88-8008-74
PCP-eFluor 710
£287.00
Each
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Estimated Shipment: 08-06-2022
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15581947
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Invitrogen™
BMS500FI-100
FITC, Propidium Iodide 488, 535/520, 617
£210.00
100 tests
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Estimated Shipment: 22-06-2022
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15501957
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Invitrogen™
BMS500FI-20
FITC, Propidium Iodide 488, 535/520, 617
£102.00
20 tests
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Estimated Shipment: 08-06-2022
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15521957
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Invitrogen™
BMS500FI-300
FITC, Propidium Iodide 488, 535/520, 617
£354.00
300 tests
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Estimated Shipment: 24-05-2022
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14819780
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Invitrogen™
88-8102-72
PE, 7-AAD
£105.00
50 tests
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15521207
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Invitrogen™
88-8102-74
PE, 7-AAD
£320.00
200 tests
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In Stock
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15531207
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Invitrogen™
88-8103-72
PE/Cy7
£144.00
50 tests
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Estimated Shipment: 30-05-2022
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15541207
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Invitrogen™
88-8103-74
PE/Cy7
£320.00
200 tests
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Estimated Shipment: 30-05-2022
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15551947
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Invitrogen™
BMS500BT-100
Biotin, Propidium Iodide NA, 535/NA, 617
£214.00
100 tests
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Estimated Shipment: 08-06-2022
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15561947
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Invitrogen™
BMS500BT-20
Biotin, Propidium Iodide NA, 535/NA, 617
£104.00
20 tests
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Estimated Shipment: 08-06-2022
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15571947
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Invitrogen™
BMS500BT-300
Biotin, Propidium Iodide NA, 535/NA, 617
£359.00
300 tests
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Estimated Shipment: 08-06-2022
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12760170
View Documents Promotion Details
Invitrogen™
88-8005-72
FITC, Propidium Iodide 488, 535/520, 617
£104.00
Each
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»
In Stock
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15581187
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Invitrogen™
88-8007-72
APC, Propidium Iodide 650, 535/660, 617
£121.00
50 tests
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Description

Description

Easily distinguish cells undergoing early and late apoptosis with eBioscience and Annexin V Apoptosis Detection kits for flow cytometry analysis. These kits utilize viability dye-conjugated annexin V to label phosphatidylserine (PS), an early marker of apoptosis, on the extracellular membrane. In late-stage apoptosis, as cell integrity is lost, both annexin V and the viability dye traverse and bind PS on the interior of the plasma membrane.

Annexins are a family of calcium-dependent phospholipid-binding proteins that preferentially bind phosphatidylserine (PS). Under normal physiologic conditions, PS is predominantly located in the inner leaflet of the plasma membrane. Upon initiation of apoptosis, PS loses its asymmetric distribution across the phospholipid bilayer and is translocated to the extracellular membrane leaflet marking cells as targets of phagocytosis. Once on the outer surface of the membrane, PS can be detected by fluorescently labeled annexin V in a calcium-dependent manner.

In early-stage apoptosis, the plasma membrane excludes viability dyes such as propidium iodide (PI), 7-AAD, or fixable viability dyes such as eFluor 450. These cells will stain with annexin V but not a viability dye, thus distinguishing cells in early apoptosis. However, in late-stage apoptosis, the cell membrane loses integrity, thereby allowing annexin V to also access PS in the interior of the cell. A viability dye can be used to resolve these late-stage apoptotic and necrotic cells (annexin V, viability dye-positive) from the early-stage apoptotic cells (annexin V positive, viability dye-negative).

Current viability stains available with the eBioscience Annexin V Apoptosis Detection kits include FITC, eFluor 450, allophycocyanin (APC), phycoerythrin (PE), PE-cyanine7, and biotin.

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