Doxycycline monohydrate, Thermo Scientific™

Doxycycline monohydrate, CAS # 17086-28-1, is the hydrated form of the tetracycline class antibiotic doxycycline.

Brand:  Thermo Scientific Alfa Aesar J63805.14

Product Code. 15445979

Description

This Thermo Scientific brand product was originally part of the Alfa Aesar product portfolio. Some documentation and label information may refer to the legacy brand. The original Alfa Aesar product / item code or SKU reference has not changed as a part of the brand transition to Thermo Scientific.

General Description

• Doxycycline monohydrate is a semi-synthetic tetracycline antibiotic with broad-spectrum activity

• It is a tetracycline with the 5beta-hydrogen group replaced by a hydroxy group

• Doxycycline monohydrate acts by binding the 30S ribosomal subunit and preventing polypeptide formation

• Doxycycline monohydrate may also act on the 50S ribosomal subunit, is a known inhibitor of collagenases, and has anti-inflammatory properties

Application

• Doxycycline can be used for study of cancers, infections, and antibiotic resistance in laboratory settings

• Doxycycline can be used experimentally to control TET genes and induce expression of genes of interest in vivo and in vitro

Chemical Identifiers

• CAS: 17086-28-1
• Molecular Weight (g/mol): 462.455
• InChI Key: FZKWRPSUNUOXKJ-CVHRZJFOSA-N
• IUPAC Name: (4S,4aR,5S,5aR,6R,12aR)-4-(dimethylamino)-1,5,10,11,12a-pentahydroxy-6-methyl-3,12-dioxo-4a,5,5a,6-tetrahydro-4H-tetracene-2-carboxamide;hydrate

• Molecular Formula: C22H26N2O9
• MDL Number: MFCD02682958
• PubChem CID: 54684461
• SMILES: CC1C2C(C3C(C(=O)C(=C(C3(C(=O)C2=C(C4=C1C=CC=C4O)O)O)O)C(=O)N)N(C)C)O.O

Specifications

• CAS: 17086-28-1
• Quantity: 25g
• MDL Number: MFCD02682958
• Solubility Information: Soluble in ethanol or methanol; Sparingly soluble in water;Soluble in dilute acids,alkali hydroxides and dimethyl sulfoxide.
• SMILES: CC1C2C(C3C(C(=O)C(=C(C3(C(=O)C2=C(C4=C1C=CC=C4O)O)O)O)C(=O)N)N(C)C)O.O
• Molecular Weight (g/mol): 462.455
• Formula Weight: 462.46 (444.44 Anhydrous)

• Color: Yellow
• Molecular Formula: C22H26N2O9
• Merck Index: 14,3440
• InChI Key: FZKWRPSUNUOXKJ-CVHRZJFOSA-N
• IUPAC Name: (4S,4aR,5S,5aR,6R,12aR)-4-(dimethylamino)-1,5,10,11,12a-pentahydroxy-6-methyl-3,12-dioxo-4a,5,5a,6-tetrahydro-4H-tetracene-2-carboxamide;hydrate
• PubChem CID: 54684461
• Chemical Name or Material: Doxycycline monohydrate

Safety and Handling

Signal Word

• Warning

Hazard Category

• Acute toxicity Category 4

Hazard Statement

• H302-Harmful if swallowed.

Precautionary Statement

• P264-Wash thoroughly after handling.
• P301+P330+P331-IF SWALLOWED: rinse mouth. Do NOT induce vomiting.
• P312-Call a POISON CENTER/doctor/if you feel unwell.