Diphenyl phosphorochloridate, 97%, Thermo Scientific Chemicals

Product Code	Brand	Quantity
11400034	Thermo Scientific Alfa Aesar A13546.18	50 g
11410034	Thermo Scientific Alfa Aesar A13546.30	250 g
11490024	Thermo Scientific Alfa Aesar A13546.0B	1000 g

Description

Diphenyl phosphorochloridate is used to prepare cyclohexyl-amidophosphoric acid diphenyl ester by reacting with cyclohexylamine. It is also used in the synthesis of alfa-substituted beta-lactams, anhydrides, esters and thioesters. It is also employed in the conversion of aldoximes to nitriles. Further, it is used in the preparation and reaction of enol phosphates, guanosine-adenosine-5',5'-triphosphate, guanosine-cytidine-5',5'-triphosphate, guanosine-uridine-5',5'-triphosphate, diguanosine-5',5'-diphosphate and diguanosine-5',5'-triphosphate. In addition to this, it serves as a phosphorylating agent for the preparation of 2-deoxy-D-galactose-3 and -6 phosphoric acids.

This Thermo Scientific Chemicals brand product was originally part of the Alfa Aesar product portfolio. Some documentation and label information may refer to the legacy brand. The original Alfa Aesar product / item code or SKU reference has not changed as a part of the brand transition to Thermo Scientific Chemicals.

Applications
Diphenyl phosphorochloridate is used to prepare cyclohexyl-amidophosphoric acid diphenyl ester by reacting with cyclohexylamine. It is also used in the synthesis of alfa-substituted beta-lactams, anhydrides, esters and thioesters. It is also employed in the conversion of aldoximes to nitriles. Further, it is used in the preparation and reaction of enol phosphates, guanosine-adenosine-5′,5′-triphosphate, guanosine-cytidine-5′,5′-triphosphate, guanosine-uridine-5′,5′-triphosphate, diguanosine-5′,5′-diphosphate and diguanosine-5′,5′-triphosphate. In addition to this, it serves as a phosphorylating agent for the preparation of 2-deoxy-D-galactose-3 and -6 phosphoric acids.

Solubility
Immiscible with water.

Notes
Moisture sensitive. Incompatible with strong bases and strong oxidizing agents.

Chemical Identifiers

• CAS: 2524-64-3
• Molecular Weight (g/mol): 268.633
• InChI Key: BHIIGRBMZRSDRI-UHFFFAOYSA-N
• PubChem CID: 75654
• SMILES: C1=CC=C(C=C1)OP(=O)(OC2=CC=CC=C2)Cl

• Molecular Formula: C12H10ClO3P
• MDL Number: MFCD00003030
• Synonym: diphenyl chlorophosphate, diphenyl phosphorochloridate, diphenylchlorophosphate, phosphorochloridic acid, diphenyl ester, chlorodiphenyl phosphate, o,o-diphenyl chlorophosphate, chlorodiphenoxyphosphine oxide, diphenoxychlorophosphine oxide, diphenyl chlorophosphonate, diphenylphosphoric acid monochloride
• IUPAC Name: [chloro(phenoxy)phosphoryl]oxybenzene

Specifications

• CAS: 2524-64-3
• Boiling Point: 145°C to 147°C (1 mmHg)
• Molecular Formula: C12H10ClO3P
• MDL Number: MFCD00003030
• Beilstein: 654130
• Synonym: diphenyl chlorophosphate, diphenyl phosphorochloridate, diphenylchlorophosphate, phosphorochloridic acid, diphenyl ester, chlorodiphenyl phosphate, o,o-diphenyl chlorophosphate, chlorodiphenoxyphosphine oxide, diphenoxychlorophosphine oxide, diphenyl chlorophosphonate, diphenylphosphoric acid monochloride
• InChI Key: BHIIGRBMZRSDRI-UHFFFAOYSA-N
• IUPAC Name: [chloro(phenoxy)phosphoryl]oxybenzene
• PubChem CID: 75654
• Percent Purity: 97%

• Density: 1.296
• Flash Point: 113°C (235°F)
• Refractive Index: 1.55
• UN Number: UN3265
• Sensitivity: Moisture sensitive
• Solubility Information: Immiscible with water.
• SMILES: C1=CC=C(C=C1)OP(=O)(OC2=CC=CC=C2)Cl
• Molecular Weight (g/mol): 268.633
• Formula Weight: 268.64
• Chemical Name or Material: Diphenyl phosphorochloridate

Safety and Handling

GHS H Statement
H314-H318
Causes severe skin burns and eye damage.
Causes serious eye damage.

P260-P264b-P280-P301+P330+P331-P303+P361+P353-P304+P340-P305+P351+P338-P310-P363-P501c

H314

missing translation for 'dotInformation' : Hazard Class: 8; Packaging Group: II

missing translation for 'einecsNumber' : 219-759-6

missing translation for 'tsca' : Yes

Recommended Storage : Ambient temperatures

RUO – Research Use Only