Dexamethasone 21-phosphate disodium salt, 98%, Thermo Scientific™

Product Code	Brand	Quantity
15466189	Thermo Scientific Alfa Aesar J64083.03	1g
15476189	Thermo Scientific Alfa Aesar J64083.06	5g

Description

This Thermo Scientific brand product was originally part of the Alfa Aesar product portfolio. Some documentation and label information may refer to the legacy brand. The original Alfa Aesar product / item code or SKU reference has not changed as a part of the brand transition to Thermo Scientific.

General Description

Dexamethasone 21-phosphate disodium salt is a sodium phosphate salt form of dexamethasone, considered to be a synthetic adrenal glucocorticoid with anti-inflammatory activity

Application

Dexamethasone 21-phosphate disodium salt binds to specific nuclear steroid receptors, interfering with NF-kB activation and apoptotic pathways

It acts as an inducer of apoptosis and inhibitor of the sodium phosphate symporter

It has been used as a positive control to study its effects on ocular shedding of herpes simplex virus type 1 in the induced reactivation and spontaneous shedding rabbit models

This compound is used to study its protective effects against cisplatin-induced ototoxicity in the inner ear of guinea pigs

Chemical Identifiers

• CAS: 2392-39-4
• Molecular Weight (g/mol): 516.41
• InChI Key: PLCQGRYPOISRTQ-FCJDYXGNSA-L
• PubChem CID: 16961
• IUPAC Name: disodium;[2-[(8S,9R,10S,11S,13S,14S,16R,17R)-9-fluoro-11,17-dihydroxy-10,13,16-trimethyl-3-oxo-6,7,8,11,12,14,15,16-octahydrocyclopenta[a]phenanthren-17-yl]-2-oxoethyl] phosphate

• Molecular Formula: C22H28FNa2O8P
• MDL Number: MFCD00079105
• Synonym: dexamethasone sodium phosphate, dexamethasone 21-phosphate disodium salt, dalalone, dexadreson, dexagro, megacort, soldesam, spersadox, decdan, solu-decadron
• ChEBI: CHEBI:4462
• SMILES: CC1CC2C3CCC4=CC(=O)C=CC4(C3(C(CC2(C1(C(=O)COP(=O)([O-])[O-])O)C)O)F)C.[Na+].[Na+]

Specifications

• CAS: 2392-39-4
• MDL Number: MFCD00079105
• Merck Index: 142943
• Solubility Information: Soluble in water. Slightly soluble in ethanol. Insoluble in dichloromethane.
• SMILES: CC1CC2C3CCC4=CC(=O)C=CC4(C3(C(CC2(C1(C(=O)COP(=O)([O-])[O-])O)C)O)F)C.[Na+].[Na+]
• Molecular Weight (g/mol): 516.41
• ChEBI: CHEBI:4462
• Percent Purity: 98%

• Molecular Formula: C22H28FNa2O8P
• Beilstein: 6473066
• Synonym: dexamethasone sodium phosphate, dexamethasone 21-phosphate disodium salt, dalalone, dexadreson, dexagro, megacort, soldesam, spersadox, decdan, solu-decadron
• InChI Key: PLCQGRYPOISRTQ-FCJDYXGNSA-L
• IUPAC Name: disodium;[2-[(8S,9R,10S,11S,13S,14S,16R,17R)-9-fluoro-11,17-dihydroxy-10,13,16-trimethyl-3-oxo-6,7,8,11,12,14,15,16-octahydrocyclopenta[a]phenanthren-17-yl]-2-oxoethyl] phosphate
• PubChem CID: 16961
• Formula Weight: 516.4
• Chemical Name or Material: Dexamethasone 21-phosphate disodium salt

Safety and Handling

Harmful if swallowed, Suspected of damaging the unborn child, May cause damage to organs through prolonged or repeated exposure

Acute toxicity (category 4), Reproductive toxicity (category 2), Specific target organ toxicity after repeated exposure (category 2)

missing translation for 'einecsNumber' : 219-243-0

missing translation for 'rtecsNumber' : TU4056000

missing translation for 'tsca' : Yes

Recommended Storage : Keep cold

RUO – Research Use Only