Dexamethasone 21-phosphate disodium salt, 98%, Thermo Scientific™

Dexamethasone 21-phosphate disodium salt, CAS # 2392-39-4, is a synthetic adrenal glucocorticoid with potent anti-inflammatory activity.

Brand:  Thermo Scientific Alfa Aesar J64083.06

Product Code. 15476189

Description

This Thermo Scientific brand product was originally part of the Alfa Aesar product portfolio. Some documentation and label information may refer to the legacy brand. The original Alfa Aesar product / item code or SKU reference has not changed as a part of the brand transition to Thermo Scientific.

General Description

Dexamethasone 21-phosphate disodium salt is a sodium phosphate salt form of dexamethasone, considered to be a synthetic adrenal glucocorticoid with anti-inflammatory activity

Application

Dexamethasone 21-phosphate disodium salt binds to specific nuclear steroid receptors, interfering with NF-kB activation and apoptotic pathways

It acts as an inducer of apoptosis and inhibitor of the sodium phosphate symporter

It has been used as a positive control to study its effects on ocular shedding of herpes simplex virus type 1 in the induced reactivation and spontaneous shedding rabbit models

This compound is used to study its protective effects against cisplatin-induced ototoxicity in the inner ear of guinea pigs

Chemical Identifiers

• CAS: 2392-39-4
• Molecular Weight (g/mol): 516.41
• InChI Key: PLCQGRYPOISRTQ-FCJDYXGNSA-L
• PubChem CID: 16961
• IUPAC Name: disodium;[2-[(8S,9R,10S,11S,13S,14S,16R,17R)-9-fluoro-11,17-dihydroxy-10,13,16-trimethyl-3-oxo-6,7,8,11,12,14,15,16-octahydrocyclopenta[a]phenanthren-17-yl]-2-oxoethyl] phosphate

• Molecular Formula: C22H28FNa2O8P
• MDL Number: MFCD00079105
• Synonym: dexamethasone sodium phosphate, dexamethasone 21-phosphate disodium salt, dalalone, dexadreson, dexagro, megacort, soldesam, spersadox, decdan, solu-decadron
• ChEBI: CHEBI:4462
• SMILES: CC1CC2C3CCC4=CC(=O)C=CC4(C3(C(CC2(C1(C(=O)COP(=O)([O-])[O-])O)C)O)F)C.[Na+].[Na+]

Specifications

• CAS: 2392-39-4
• MDL Number: MFCD00079105
• Beilstein: 6473066
• Synonym: dexamethasone sodium phosphate, dexamethasone 21-phosphate disodium salt, dalalone, dexadreson, dexagro, megacort, soldesam, spersadox, decdan, solu-decadron
• InChI Key: PLCQGRYPOISRTQ-FCJDYXGNSA-L
• IUPAC Name: disodium;[2-[(8S,9R,10S,11S,13S,14S,16R,17R)-9-fluoro-11,17-dihydroxy-10,13,16-trimethyl-3-oxo-6,7,8,11,12,14,15,16-octahydrocyclopenta[a]phenanthren-17-yl]-2-oxoethyl] phosphate
• PubChem CID: 16961
• Formula Weight: 516.4
• Chemical Name or Material: Dexamethasone 21-phosphate disodium salt

• Molecular Formula: C22H28FNa2O8P
• Quantity: 5g
• Merck Index: 142943
• Solubility Information: Soluble in water. Slightly soluble in ethanol. Insoluble in dichloromethane.
• SMILES: CC1CC2C3CCC4=CC(=O)C=CC4(C3(C(CC2(C1(C(=O)COP(=O)([O-])[O-])O)C)O)F)C.[Na+].[Na+]
• Molecular Weight (g/mol): 516.41
• ChEBI: CHEBI:4462
• Percent Purity: 98%

Safety and Handling

Product Identifier

• Dexamethasone 21-phosphate disodium salt

Signal Word

• Warning

Hazard Category

• Acute toxicity Category 4
• Reproductive toxicity Category 2
• Specific target organ toxicity after repeated exposure Category 2

Hazard Statement

• H302-Harmful if swallowed.
• H361d-Suspected of damaging the unborn child.
• H373-May cause damage to organs.

Precautionary Statement

• P201-Obtain special instructions before use.
• P264-Wash face, hands and anyexposed skin thoroughly after handling.
• P280-Wear protective gloves/protective clothing/eye protection/face protection.
• P301+P330+P331-IF SWALLOWED: rinse mouth. Do NOT induce vomiting.
• P312-Call a POISON CENTER/doctor/if you feel unwell.

Supplemental information

• MIXTURE LIST-Contains : Dexamethasone 21-phosphate disodium salt