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Tocris Bioscience™ DAPT
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Product Code. 18083842
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10 mg
50 mg
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10mg
50mg
Product Code. Quantity unitSize
18083842 10 mg 10mg
18024422 50 mg 50mg
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Product Code. 18083842

Brand: Tocris Bioscience™ 2634/10

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204.00 GBP valid until 2026-03-31
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This item is not returnable. View return policy

Description

Gamma γ-secretase inhibitor; induces neuronal differentiation; blocks Notch signaling

DAPT is a γ-secretase inhibitor. DAPT reduces Aβ40 and Aβ42 levels in human primary neuronal cultures (IC50 values are 115 and 200 nM for total Aβ and Aβ42 respectively) and in brain extract, cerebrospinal fluid and plasma in vivo. DAPT has no effect on APPα and APPβ levels. DAPT blocks Notch signaling in hybrid human-mouse fetal thymus organ culture (FTOC) and causes ESCs to commit to neuronal differentiation. DAPT can be used in a small molecule cocktail to derive cortical neurons from hPSCs and to maintain hepatocytes in culture. DAPT also promotes the formation of cone photoreceptors in retinal organoids.

For more information about how DAPT may be used, see our protocols: Accelerated Induction of Cortical Neurons from hiPSCs, Human iPSC-derived Myoblasts, Generating Midbrain Dopaminergic Neurons from hPSCs .

DAPT synthesized to Ancillary Material Grade also available.

TRUSTED_SUSTAINABILITY

Chemical Identifiers

CAS 208255-80-5
Molecular Formula C23H26F2N2O4

Specifications

Quantity 10 mg
Formula Weight 432.46
Purity >99%
Molecular Weight (g/mol) 432.468
Chemical Name or Material DAPT
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