Invitrogen™ CRX Polyclonal Antibody

Rabbit Polyclonal Antibody

Product Code	Brand	Quantity
17198993	Invitrogen™ PA5111077	100 μL
17109003	Invitrogen™ PA5111078	100 μL

Description

Immunogen sequence: PLPEAQRAGL VASGPSLTSA PYAMTYAPAS AFCSSPSAYG SPSSYFSGLD PYLSPMVPQL GGPALSPLSG PSVGPSLAQS PTSLSGQSYG AYSPVDSLEF K Highest antigen sequence indentity to the following orthologs: Rat - 96%, Mouse - 97%.

The cone-rod homeobox-containing gene (CRX) encodes a transcription factor that coordinates the expression of several photoreceptor genes in the developing retina, including opsin and rhodopsin. Specifically, CRX binds the OTX motif (TAATCC/A) upstream from photoreceptor genes. The CRX gene is also expressed in the pinealocytes of the pineal gland and may regulate pineal circadian activity by controling the expression of melatonin synthesis genes. Furthermore, CRX(-) mice exhibit disruption of circadian rhythms. The human CRX gene maps to chromosome 19q13.3 within the region of the cone-rod dystrophy-2 locus (CORD2). Mutations in the CRX gene are implicated in the visual pathologies of CORD, Leber congenital amaurosis (LCA) and retinitis pigmentosa (RP). All characterized CRX gene mutations produce disease in heterozygotes although there is no known correlation between the pathologic phenotype and genetic mutation. Missense mutations of the CRX gene affect the homeobox domain, whereas frameshift mutations affect the OTX domain.

Specifications

• Antigen: CRX
• Content And Storage: Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
• Classification: Polyclonal
• Form: Liquid
• Isotype: IgG
• Target Species: Human
• Gene: Crx
• Gene Alias: Cone rod homeobox; cone-rod homeobox; cone-rod homeobox containing; cone-rod homeobox protein; CORD 2; CORD2; CRD; CRX; Crx1; LCA 7; LCA7; orthodenticle homeobox 3; OTX; OTX 3; OTX3
• Gene Symbols: Crx
• Primary or Secondary: Primary
• Purification Method: Antigen affinity chromatography

• Concentration: 0.10 mg/mL
• Applications: Immunohistochemistry (Paraffin), Western Blot
• Conjugate: Unconjugated
• Host Species: Rabbit
• Regulatory Status: RUO
• Formulation: PBS with 40% glycerol and 0.02% sodium azide; pH 7.2
• Gene Accession No.: O43186
• Gene ID (Entrez): 1406
• Immunogen: Recombinant Protein corresonding to Human CRX. Recombinant protein control fragment (Product #RP-97574).
• Product Type: Antibody