Complement factor B Mouse anti-Human, Clone: 8D2B6, Proteintech

Mouse Monoclonal Antibody

Brand:  Proteintech 66154-1-IG-20UL

Product Code. 16817775

Description

This gene encodes complement factor B, a component of the alternative pathway of complement activation. Factor B circulates in the blood as a single chain polypeptide. Upon activation of the alternative pathway, it is cleaved by complement factor D yielding the noncatalytic chain Ba and the catalytic subunit Bb. The active subunit Bb is a serine protease which associates with C3b to form the alternative pathway C3 convertase. Bb is involved in the proliferation of preactivated B lymphocytes, while Ba inhibits their proliferation. This gene localizes to the major histocompatibility complex (MHC) class III region on chromosome 6. This cluster includes several genes involved in regulation of the immune reaction. Polymorphisms in this gene are associated with a reduced risk of age-related macular degeneration. The polyadenylation site of this gene is 421 bp from the 5′ end of the gene for complement component 2.

Specifications

• Antigen: Complement factor B
• Classification: Monoclonal
• Concentration: 0.6 mg/mL
• Formulation: PBS with 50% glycerol and 0.02% sodium azide; pH 7.3
• Gene Accession No.: P00751
• Gene Symbols: CFB
• Immunogen: Complement factor B Fusion Protein Ag19107
• Quantity: 20 μL
• Primary or Secondary: Primary
• Target Species: Human
• Product Type: Antibody
• Isotype: IgM

• Applications: Western Blot, Immunohistochemistry (Paraffin)
• Clone: 8D2B6
• Conjugate: Unconjugated
• Gene: CFB
• Gene Alias: BF, BFD, C3/C5 convertase, CFAB, CFB, Complement factor B, FB, FBI12, GBG, Glycine rich beta glycoprotein, H2 Bf, PBF2, Properdin factor B
• Host Species: Mouse
• Purification Method: Antigen Affinity Chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 629
• Content And Storage: -20°C
• Form: Liquid