Complement factor B Mouse anti-Human, Clone: 8D2B6, Proteintech

Mouse Monoclonal Antibody

Product Code	Brand	Quantity
16817775	Proteintech 66154-1-IG-20UL	20 μL
16807775	Proteintech 66154-1-IG-150UL	150 μL

Description

This gene encodes complement factor B, a component of the alternative pathway of complement activation. Factor B circulates in the blood as a single chain polypeptide. Upon activation of the alternative pathway, it is cleaved by complement factor D yielding the noncatalytic chain Ba and the catalytic subunit Bb. The active subunit Bb is a serine protease which associates with C3b to form the alternative pathway C3 convertase. Bb is involved in the proliferation of preactivated B lymphocytes, while Ba inhibits their proliferation. This gene localizes to the major histocompatibility complex (MHC) class III region on chromosome 6. This cluster includes several genes involved in regulation of the immune reaction. Polymorphisms in this gene are associated with a reduced risk of age-related macular degeneration. The polyadenylation site of this gene is 421 bp from the 5′ end of the gene for complement component 2.

Specifications

• Antigen: Complement factor B
• Concentration: 0.6 mg/mL
• Classification: Monoclonal
• Form: Liquid
• Regulatory Status: RUO
• Formulation: PBS with 50% glycerol and 0.02% sodium azide; pH 7.3
• Gene Alias: BF, BFD, C3/C5 convertase, CFAB, CFB, Complement factor B, FB, FBI12, GBG, Glycine rich beta glycoprotein, H2 Bf, PBF2, Properdin factor B
• Gene Symbols: CFB
• Isotype: IgM
• Purification Method: Antigen Affinity Chromatography
• Product Type: Antibody

• Clone: 8D2B6
• Applications: Western Blot, Immunohistochemistry (Paraffin)
• Conjugate: Unconjugated
• Host Species: Mouse
• Target Species: Human
• Gene Accession No.: P00751
• Gene ID (Entrez): 629
• Immunogen: Complement factor B Fusion Protein Ag19107
• Primary or Secondary: Primary
• Content And Storage: -20°C
• Gene: CFB