CNOT1 Mouse anti-Human, Clone: 1A10A11, Proteintech

Mouse Monoclonal Antibody

Product Code	Brand	Quantity
16868445	Proteintech 66507-1-IG-20UL	20 μL
16858445	Proteintech 66507-1-IG-150UL	150 μL

Description

This is a rabbit polyclonal antibody raised against a region from the C-terminal CNOT1 of human origin. CNOT1 exists as many isoforms. Isoform one is about 267 kDa and isoform four is about 173 kDa.

Scaffolding component of the CCR4-NOT complex which is one of the major cellular mRNA deadenylases and is linked to various cellular processes including bulk mRNA degradation, miRNA-mediated repression, translational repression during translational initiation and general transcription regulation. Additional complex functions may be a consequence of its influence on mRNA expression. Its scaffolding function implies its interaction with the catalytic complex module and diverse RNA-binding proteins mediating the complex recruitment to selected mRNA 3′UTRs. Involved in degradation of AU-rich element (ARE)-containing mRNAs probably via association with ZFP36. Mediates the recruitment of the CCR4-NOT complex to miRNA targets and to the RISC complex via association with TNRC6A, TNRC6B or TNRC6C. Acts as a transcriptional repressor. Represses the ligand-dependent transcriptional activation by nuclear receptors. Involved in the maintece of emryonic stem (ES) cell identity.

Specifications

• Antigen: CNOT1
• Concentration: 1 mg/mL
• Classification: Monoclonal
• Form: Liquid
• Regulatory Status: RUO
• Formulation: PBS with 50% glycerol and 0.1% sodium azide; pH 7.3
• Gene Alias: AD 005, CCR4 associated factor 1, CDC39, CNOT1, hNOT1, KIAA1007, NOT1, NOT1H
• Gene Symbols: CNOT1
• Isotype: IgG1
• Purification Method: Protein G
• Product Type: Antibody

• Clone: 1A10A11
• Applications: Immunocytochemistry, Immunohistochemistry (Paraffin), Western Blot, Immunofluorescence
• Conjugate: Unconjugated
• Host Species: Mouse
• Target Species: Human
• Gene Accession No.: A5YKK6
• Gene ID (Entrez): 23019
• Immunogen: CNOT1 Fusion Protein Ag5623
• Primary or Secondary: Primary
• Content And Storage: -20°C
• Gene: CNOT1