Invitrogen™ CHOP Monoclonal Antibody (K49008_7F7), Invitrogen™

Mouse Monoclonal Antibody

Brand:  Invitrogen™ MA556154

Product Code. 30202036

Description

Sequence of this protein is as follows: MAAESLPFSF GTLSSWELEA WYEDLQEVLS SDENGGTYVS PPGNEEEESK IFTTLDPASL AWLTEEEPEP AEVTSTSQSP HSPDSSQSSL AQEEEEEDQG RTRKRKQSGH SPARAGKQRM KEKEQENERK VAQLAEENER LKQEIERLTR EVEATRRALI DRMVNLHQA

GADD153 is a small nuclear protein that is capable of dimerizing with transcription factors C/EBP alpha and beta. Once dimerized, this complex inhibits the normal binding and function of C/EBP to classical binding sites. Inversely, the C/EBP GADD153 dimer gains binding activity to other non classical C/EBP stress related targets. Under normal cellular conditions this protein is not expressed in detectable levels, but is highly unregulated during times of cellular/ER stress. Examples of GADD153 inducing stress include: treatment with tunicamycin, nutrient starvation and reducing agents that interfere with the calcium flux across the ER membrane.

Specifications

• Antigen: CHOP
• Classification: Monoclonal
• Concentration: 1 mg/mL
• Formulation: PBS with 50% glycerol, 0.5% BSA and 0.09% sodium azide
• Gene Accession No.: P35638
• Gene Symbols: DDIT3
• Immunogen: Recombinant human DDIT3 (immunogen range is 1-169).
• Quantity: 200 μL
• Primary or Secondary: Primary
• Target Species: Human
• Product Type: Antibody
• Isotype: IgG1

• Applications: Western Blot
• Clone: K49008_7F7
• Conjugate: Unconjugated
• Gene: DDIT3
• Gene Alias: C/EBP homologous protein; C/EBP homoologous protein 10; C/EBP zeta; C/EBP-homologous protein; C/EBP-homologous protein 10; CCAAT/enhancer-binding protein homologous protein; CEBPZ; CHOP; CHOP10; CHOP-10; Ddit3; DDIT-3; ddit3.L; DNA damage inducible transcript 3; DNA damage inducible transcript 3 L homeolog; DNA damage-inducible transcript 3 protein; DNA-damage inducible transcript 3; DNA-damage-inducible transcript 3; GADD153; growth arrest and DNA damage-inducible; growth arrest and DNA damage-inducible protein GADD153; Growth arrest and DNA-damage-inducible protein GADD153; MGC4154; transcription factor GADD153; Xchop; XELAEV_18013440mg
• Host Species: Mouse
• Purification Method: Protein A
• Regulatory Status: RUO
• Gene ID (Entrez): 1649
• Content And Storage: Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
• Form: Liquid