CEP135 Rabbit anti-Canine, Human, Polyclonal, Proteintech

Rabbit Polyclonal Antibody

Product Code	Brand	Quantity
16862905	Proteintech 24428-1-AP-20UL	20 μL
16852905	Proteintech 24428-1-AP-150UL	150 μL

Description

LATS1 is a putative serine/threonine kinase that localizes to the mitotic apparatus and complexes with cell cycle controller CDC2 kinase in early mitosis. The protein is phosphorylated in a cell-cycle dependent manner, with late prophase phosphorylation remaining through metaphase. The N-terminal region of the protein binds CDC2 to form a complex showing reduced H1 histone kinase activity, indicating a role as a negative regulator of CDC2/cyclin A. In addition, the C-terminal kinase domain binds to its own N-terminal region, suggesting potential negative regulation through interference with complex formation via intramolecular binding. Biochemical and genetic data suggest a role as a tumor suppressor. This is supported by studies in knockout mice showing development of soft-tissue sarcomas, ovarian stromal cell tumors and a high sensitivity to carcinogenic treatments.

Specifications

• Antigen: CEP135
• Applications: Immunofluorescence, Western Blot, Immunocytochemistry
• Conjugate: Unconjugated
• Host Species: Rabbit
• Target Species: Canine, Human
• Gene Accession No.: Q66GS9
• Gene ID (Entrez): 482157, 9662
• Immunogen: CEP135 Fusion Protein Ag19122
• Primary or Secondary: Primary
• Content And Storage: -20°C
• Gene: CEP135

• Concentration: 0.22 mg/mL
• Classification: Polyclonal
• Form: Liquid
• Regulatory Status: RUO
• Formulation: PBS with 50% glycerol and 0.1% sodium azide; pH 7.3
• Gene Alias: centrosomal protein 135kDa, Centrosomal protein 4, Centrosomal protein of 135 kDa, CEP135, CEP4, KIAA0635
• Gene Symbols: CEP135
• Isotype: IgG
• Purification Method: Antigen Affinity Chromatography
• Product Type: Antibody