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  6. CEP135 Rabbit anti-Canine, Human, Polyclonal, Proteintech

CEP135 Rabbit anti-Canine, Human, Polyclonal, Proteintech

Product Code. 16862905 Shop All Proteintech Products
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20 μL
150 μL
Unit Size:
150µL
20µL
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16862905 20 μL 20µL
16852905 150 μL 150µL
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Product Code. 16862905 Supplier Proteintech Supplier No. 244281AP20UL

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Description

Rabbit Polyclonal Antibody

LATS1 is a putative serine/threonine kinase that localizes to the mitotic apparatus and complexes with cell cycle controller CDC2 kinase in early mitosis. The protein is phosphorylated in a cell-cycle dependent manner, with late prophase phosphorylation remaining through metaphase. The N-terminal region of the protein binds CDC2 to form a complex showing reduced H1 histone kinase activity, indicating a role as a negative regulator of CDC2/cyclin A. In addition, the C-terminal kinase domain binds to its own N-terminal region, suggesting potential negative regulation through interference with complex formation via intramolecular binding. Biochemical and genetic data suggest a role as a tumor suppressor. This is supported by studies in knockout mice showing development of soft-tissue sarcomas, ovarian stromal cell tumors and a high sensitivity to carcinogenic treatments.

Specifications

Antigen CEP135
Applications Immunofluorescence, Western Blot, Immunocytochemistry
Classification Polyclonal
Concentration 0.22 mg/mL
Conjugate Unconjugated
Formulation PBS with 50% glycerol and 0.1% sodium azide; pH 7.3
Gene CEP135
Gene Accession No. Q66GS9
Gene Alias centrosomal protein 135kDa, Centrosomal protein 4, Centrosomal protein of 135 kDa, CEP135, CEP4, KIAA0635
Gene Symbols CEP135
Host Species Rabbit
Immunogen CEP135 Fusion Protein Ag19122
Purification Method Antigen Affinity Chromatography
Quantity 20 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 482157, 9662
Target Species Canine, Human
Content And Storage -20°C
Product Type Antibody
Form Liquid
Isotype IgG
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