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Thermo Scientific™ CellSensor™ NFkB-bla ME-180 Cell Line

Product Code. 10460014
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Quantity:
1 Vial
Unit Size:
Each
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Product Code. 10460014

Brand: Thermo Scientific™ K1667

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Description

The CellSensor™ NFκB-bla ME-180 cell line contains a beta-lactamase reporter gene under control of the Nuclear Factor Kappa B (NFκB) response element stably integrated into ME-180 cells.

The CellSensor™ NFκB-bla ME-180 cell line contains a beta-lactamase reporter gene under control of the Nuclear Factor Kappa B (NFκB) response element stably integrated into ME-180 cells. The cell line was created through fluorescence activated cell sorting (FACS) of cells responsive to stimulation of the NFκB pathway with tumor necrosis factor alpha (TNFα). The cell line was validated for DMSO tolerance, incubation time with stimulant, and substrate loading conditions. The CellSensor™ NFκB-bla ME-180 cell line responds to agonist treatment as expected from literature and can be adapted for high-throughput screening for agonists or antagonists of the NFκB pathway with compound libraries. Candidate drugs can also be tested for dose response against this cell line. Academic and non-profit customers, please inquire for special pricing.

TRUSTED_SUSTAINABILITY

Specifications

Assay Entry Cell-based beta lactamase reporter gene
Cell State Dividing Cells
Content And Storage CellSensor™ Cell Lines are shipped on dry ice. Store in liquid nitrogen immediately upon receipt, or thaw for immediate use.
Description CellSensor™ NFkB-bla ME-180 Cell Line, 1Vial, ∽ 9,600,000 cells/vial at 9,600,000 cells/mL Quantity of Cells, NFkB-bla ME-180 Cell Line, Fluorescent Detection Method, CellSensor™ Druggable Target, Adherent Growth Properties, Liquid Nitrogen Storage
Detection Method Fluorescent
For Use With (Application) Pharma and biopharma, drug discovery and development, target and lead identification and validation, pathway biology, cellular pathway analysis assays, cellsensor™ cellular pathway assays
Includes beta-lactamase reporter gene under control of the nuclear factor Kappa B (NFkB) response element stably integrated into ME-180 cells
Product Line CellSensor
Quantity 1 Vial
Sample Type NFkB-bla ME-180
Target Entry TNF alpha, NIK, TLR, I kappa B, IRAK, IKK, NF-kappa B pathway
Type Cell Line
Cell Line ME-180
System Type CellSensor™
Druggable Target Signaling Pathway
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For Research Use Only. Not for use in diagnostic procedures.

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