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Thermo Scientific™ CellSensor™ ISRE-bla HEK293T Cell Line

Product Code. 10563084
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Quantity:
1 Vial
Unit Size:
Each
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Product Code. 10563084

Brand: Thermo Scientific™ K1655

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Description

The CellSensor™ ISRE-bla HEK 293T cell line is responsive to interferon alpha and can be used to probe the JAK/STAT signaling pathway.

Interferon cell signaling is a critical pathway involved in viral defense and autoimmune disease. The CellSensor™ ISRE-bla HEK 293T cell line is responsive to interferon alpha and can be used to probe the JAK/STAT signaling pathway. The CellSensor™ ISRE-bla HEK 293T cell line contains the β-lactamase reporter gene under the control of the interferon stimulated response element (ISRE). This cell line was engineered by transduction of the ISRE-bla construct into HEK 293T cells by lentivirus. Flow cytometry was then used to isolate a pool of clones responsive to interferon alpha a stimulation. A dose response curve for this assay against interferon alpha is available in the validation packet. Academic and non-profit customers, please inquire for special pricing.

TRUSTED_SUSTAINABILITY

Specifications

Assay Entry Cell-based beta lactamase reporter gene
Cell State Dividing Cells
Content And Storage CellSensor™ Cell Lines are shipped on dry ice. Store in liquid nitrogen immediately upon receipt, or thaw for immediate use.
For Use With (Application) Cytokines, Signaling Pathway
Product Line CellSensor
Quantity 1 Vial
Target Entry JAK/STAT (Type I IFN) pathway, TYK2, JAK1
Type Dividing Cells
System Type CellSensor™
Druggable Target Signaling Pathway

For Research Use Only. Not for use in diagnostic procedures.

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