CD83 Mouse, anti-Human, APC, Clone: HB15e, STEMCELL Technologies

Mouse Monoclonal Antibody

Brand:  Stemcell Technologies 60107AZ

Product Code. 17109061

Description

• The HB15e antibody reacts with CD83, an ∼45 kDa type I transmembrane glycoprotein and member of the Siglec protein family, containing an extracellular V-type Ig-like domain and a C-terminal cytoplasmic tail
• A soluble form of CD83 has also been identified
• CD83 is expressed predominantly on circulating and tissue dendritic cells, including Langerhan cells and interdigitating reticulum cells
• It is expressed weakly on activated lymphocytes and may also be found on neutrophils, monocytes and macrophages
• Expression of CD83 is typically transient, except on dendritic cells, and correlates with upregulation of HLA class II antigen
• Its function, though ill-defined, is essential for the development and maintenance of the immune system and evidence suggests it may be involved in cell adhesion and signaling, antigen presentation, and lymphocyte activation
• The epitope on CD83 bound by the HB15e antibody reportedly overlaps with that of antibody 1E11

Specifications

• Antigen: CD83
• Classification: Monoclonal
• Conjugate: APC
• Quantity: 100 Tests
• Target Species: Baboon, Cynomolgus, Rhesus Monkey, Chimpanzee, Human
• Cell Type: Dendritic Cells

• Applications: Immunoblot, Flow Cytometry, Immunohistochemistry
• Clone: HB15e
• Host Species: Mouse
• Primary or Secondary: Primary
• Isotype: IgG1 κ