CD68 Monoclonal Antibody (eBioY1/82A (Y1/82A)), eBioscience™, Invitrogen™

Mouse Monoclonal Antibody

Brand:  Affymetrix eBioscience 14-0689-95

Product Code. 17170512

Description

The eBioY1/82 antibody reacts with CD68 which belongs to the sialomucin family and is closely related to the family of lysosomal-associated membrane proteins (lamps) and scavenger receptor. CD68 is predominantly an intracellular protein, found mainly in the late endosomal compartment but can be detected in smaller amounts on the surface of cells of mainly myeloid derived cells; monocytes and macrophages, dendritic cells (and in some langerhan cells), neutrophils, basophils mast cells, myeloid progenitor cells, and a subset of CD34+ hemopoietic bone marrow progenitor cells. The function has not been fully elucidated but based on it's homolgy and structure suggests a role in antigen processing or presentation and protection of the lysosomal membrane from hydrolytic enzymes. Reports have also seen expression in activated T cells, and about 40% of peripheral blood B-lymphocytes and 50% of all B-ALL. Staining with eBioY1/82A shows surface staining on B cells and a minor percentage of monocytes while intracellular staining results in about 50% of B cells and most monocytes.

CD68 Monoclonal antibody specifically detects CD68 in Human samples. It is validated for Flow Cytometry, Immunohistochemistry (Frozen)

Specifications

• Antigen: CD68
• Classification: Monoclonal
• Concentration: 0.5 mg/mL
• Formulation: PBS with 0.09% sodium azide; pH 7.2
• Gene Accession No.: P34810
• Host Species: Mouse
• Quantity: 10 mg
• Primary or Secondary: Primary
• Target Species: Human
• Product Type: Antibody
• Isotype: IgG2b κ

• Applications: Flow Cytometry, Immunohistochemistry (Frozen)
• Clone: eBioY1/82A (Y1/82A)
• Conjugate: Unconjugated
• Gene: Cd68
• Gene Alias: CD68; CD68 antigen; CD68 molecule; Gp110; LAMP4; macrophage antigen CD68; macrosialin; SCARD1; scavenger receptor class D, member 1; similar to CD68 antigen
• Purification Method: Affinity chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 968
• Content And Storage: 4° C
• Form: Liquid