CD5 Mouse, anti-Human, APC, Clone: UCHT2, STEMCELL Technologies

Mouse Monoclonal Antibody

Brand:  Stemcell Technologies 60082AZ.1

Product Code. 17188921

Description

• The UCHT2 antibody reacts with CD5, an ∼67 kDa single-chain type I glycoprotein and member of the scavenger receptor superfamily, which is constitutively expressed on thymocytes, T cells, B cell subsets, peripheral blood dendritic cells and some leukemia and lymphoma cells, including chronic B lymphocytic leukemia (B-CLL) cells
• CD5 is expressed at low levels on thymocytes and at high density on mature T cells
• Putative ligands include CD5L and CD72
• CD5 modulates T and B cell receptor signaling, thymocyte maturation, and T cell/B cell interactions via its physical and functional associations with the T cell receptor/CD3 complex and the B cell receptor
• Studies with CD5 knockout mice indicate that CD5 negatively regulates antigen receptor-mediated signaling in thymocytes and mature T cells
• The UCHT2 antibody binds to epitope 2 located in the extracellular domain of CD5

Specifications

• Antigen: CD5
• Classification: Monoclonal
• Conjugate: APC
• Quantity: 25 Tests
• Target Species: Cynomolgus, Rhesus Monkey, Chimpanzee, Human
• Cell Type: T Cells

• Applications: Immunohistochemistry, Western Blot, Flow Cytometry, Immunocytochemistry
• Clone: UCHT2
• Host Species: Mouse
• Primary or Secondary: Primary
• Isotype: IgG1 κ