Invitrogen™ CD42b Recombinant Rabbit Monoclonal Antibody (6Y2I1)

Rabbit Recombinant Monoclonal Antibody

Brand:  Invitrogen™ MA558034

Product Code. 30284543

Description

Immunogen sequence: HPHPICEVSK VASHLEVNCD KRNLTALPPD LPKDTTILHL SENLLYTFSL ATLMPYTRLT QLNLDRCELT KLQVDGTLPV LGTLDLSHNQ LQSLPLLGQT LPALTVLDVS FNRLTSLPLG ALRGLGELQE LYLKGNELKT LPPGLLTPTP KLEKLSLANN NLTELPAGLL NGLENLDTLL LQENSLYTIP KGFFGSHLLP FAFLHGNPWL CNCEILYFRR WLQDNAENVY VWKQGVDVKA MTSNVASVQC DNSDKFPVYK YPGKGCPTLG DEGDTDLYDY YPEEDTEGDK VRATRTVVKF PTKAHTTPWG LFYSWSTASL DSQMPSSLHP TQESTKEQTT FPPRWTPNFT LHMESITFSK TPKSTTEPTP SPTTSEPVPE PAPNMTTLEP TPSPTTPEPT SEPAPSPTTP EPTSEPAPSP TTPEPTSEPA PSPTTPEPTP IPTIATSPTI LVSATSLITP KSTFLTTTKP VSLLESTKKT IPELDQPPKL RGVLQGHLES SRNDPFLHPD FCCLLPL.

CD42b is a platelet activation marker involved in the process of coagulation as an aggregating factor. It interacts with extracellular matrix as well as with adhesion molecules. CD42b expression and activation seems to be regulated by VEGF and PDGF. CD42b composes together with GPIb beta, GPIX and GPV the GPIb-IX-V receptor complex critical in the process of platelet-rich thrombus formation by tethering the platelet to a thrombogenic surface. CD42b binds to von Willebrand factor (VWF) exposed at a site of vascular injury, as well as to thrombin, coagulation factors XI and XII, high molecular wight kininogen, TSP-1, integrin Mac-1 and P-selectin. The extracellular domain of CD42b by its interactions also contributes to metastasis. Further, CD42b antigen is expressed on platelets and on megakaryocytes in bone marrow. Several polymorphisms and mutations have been described in the CD42b, some of which are the cause of Bernard-Soulier syndromes and platelet-type von Willebrand disease.

Specifications

• Antigen: CD42b
• Classification: Recombinant Monoclonal
• Concentration: 1.01 mg/mL
• Formulation: PBS with 0.05% BSA, 50% glycerol and 0.09% sodium azide; pH 7.3
• Gene Accession No.: P07359
• Gene Symbols: Gp1ba
• Immunogen: Recombinant fusion protein containing a sequence corresponding to amino acids 15-531 of human CD42b (NP_000164.5).
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human
• Product Type: Antibody
• Isotype: IgG

• Applications: ELISA, Immunohistochemistry (Paraffin)
• Clone: 6Y2I1
• Conjugate: Unconjugated
• Gene: Gp1ba
• Gene Alias: Antigen CD42b-alpha; BDPLT1; BDPLT3; BSS; CD42a; CD42B; CD42b-alpha; DBPLT3; Glycocalicin; glycoprotein 1b, alpha polypeptide; glycoprotein Ib (platelet), alpha polypeptide; glycoprotein Ib platelet alpha subunit; glycoprotein Ib platelet subunit alpha; glycoprotein Ibalpha; GP1B; GP1BA; GPIB; GPIb alpha; GP-Ib alpha; GPIbA; GPIbalpha; GPIX; GP-IX; MGC34595; mutant platelet membrane glycoprotein Ib-alpha; platelet glycoprotein Ib alpha chain; platelet glycoprotein Ib alpha polypeptide; Platelet GPIX; platelet membrane glycoprotein 1b-alpha subunit; platelet membrane glycoprotein Ib-alpha; VWDP
• Host Species: Rabbit
• Purification Method: Protein A
• Regulatory Status: RUO
• Gene ID (Entrez): 2811
• Content And Storage: -20°C, Avoid Freeze/Thaw Cycles
• Form: Liquid