Invitrogen™ CD42b Recombinant Rabbit Monoclonal Antibody (6Y2I1)

Rabbit Recombinant Monoclonal Antibody

Product Code	Brand	Quantity
30283938	Invitrogen™ MA558033	20 μL
30284543	Invitrogen™ MA558034	100 μL

Descripción

Immunogen sequence: HPHPICEVSK VASHLEVNCD KRNLTALPPD LPKDTTILHL SENLLYTFSL ATLMPYTRLT QLNLDRCELT KLQVDGTLPV LGTLDLSHNQ LQSLPLLGQT LPALTVLDVS FNRLTSLPLG ALRGLGELQE LYLKGNELKT LPPGLLTPTP KLEKLSLANN NLTELPAGLL NGLENLDTLL LQENSLYTIP KGFFGSHLLP FAFLHGNPWL CNCEILYFRR WLQDNAENVY VWKQGVDVKA MTSNVASVQC DNSDKFPVYK YPGKGCPTLG DEGDTDLYDY YPEEDTEGDK VRATRTVVKF PTKAHTTPWG LFYSWSTASL DSQMPSSLHP TQESTKEQTT FPPRWTPNFT LHMESITFSK TPKSTTEPTP SPTTSEPVPE PAPNMTTLEP TPSPTTPEPT SEPAPSPTTP EPTSEPAPSP TTPEPTSEPA PSPTTPEPTP IPTIATSPTI LVSATSLITP KSTFLTTTKP VSLLESTKKT IPELDQPPKL RGVLQGHLES SRNDPFLHPD FCCLLPL.

CD42b is a platelet activation marker involved in the process of coagulation as an aggregating factor. It interacts with extracellular matrix as well as with adhesion molecules. CD42b expression and activation seems to be regulated by VEGF and PDGF. CD42b composes together with GPIb beta, GPIX and GPV the GPIb-IX-V receptor complex critical in the process of platelet-rich thrombus formation by tethering the platelet to a thrombogenic surface. CD42b binds to von Willebrand factor (VWF) exposed at a site of vascular injury, as well as to thrombin, coagulation factors XI and XII, high molecular wight kininogen, TSP-1, integrin Mac-1 and P-selectin. The extracellular domain of CD42b by its interactions also contributes to metastasis. Further, CD42b antigen is expressed on platelets and on megakaryocytes in bone marrow. Several polymorphisms and mutations have been described in the CD42b, some of which are the cause of Bernard-Soulier syndromes and platelet-type von Willebrand disease.

Especificaciones

• Antigen: CD42b
• Concentration: 1.01 mg/mL
• Applications: ELISA, Immunohistochemistry (Paraffin)
• Conjugate: Unconjugated
• Host Species: Rabbit
• Regulatory Status: RUO
• Formulation: PBS with 0.05% BSA, 50% glycerol and 0.09% sodium azide; pH 7.3
• Gene Accession No.: P07359
• Gene ID (Entrez): 2811
• Immunogen: Recombinant fusion protein containing a sequence corresponding to amino acids 15-531 of human CD42b (NP_000164.5).
• Product Type: Antibody

• Clone: 6Y2I1
• Content And Storage: -20°C, Avoid Freeze/Thaw Cycles
• Classification: Recombinant Monoclonal
• Form: Liquid
• Isotype: IgG
• Target Species: Human
• Gene: Gp1ba
• Gene Alias: Antigen CD42b-alpha; BDPLT1; BDPLT3; BSS; CD42a; CD42B; CD42b-alpha; DBPLT3; Glycocalicin; glycoprotein 1b, alpha polypeptide; glycoprotein Ib (platelet), alpha polypeptide; glycoprotein Ib platelet alpha subunit; glycoprotein Ib platelet subunit alpha; glycoprotein Ibalpha; GP1B; GP1BA; GPIB; GPIb alpha; GP-Ib alpha; GPIbA; GPIbalpha; GPIX; GP-IX; MGC34595; mutant platelet membrane glycoprotein Ib-alpha; platelet glycoprotein Ib alpha chain; platelet glycoprotein Ib alpha polypeptide; Platelet GPIX; platelet membrane glycoprotein 1b-alpha subunit; platelet membrane glycoprotein Ib-alpha; VWDP
• Gene Symbols: Gp1ba
• Primary or Secondary: Primary
• Purification Method: Protein A