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  6. Invitrogen™ CD42b Recombinant Rabbit Monoclonal Antibody (6Y2I1)

Invitrogen™ CD42b Recombinant Rabbit Monoclonal Antibody (6Y2I1)

Product Code. p-200111575
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100 μL
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20µL
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Product Code. Quantity unitSize
30283938 20 μL 20µL
30284543 100 μL 100µL
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Product Code. 30283938 Supplier Invitrogen™ Supplier No. MA558033

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Description

Rabbit Recombinant Monoclonal Antibody

Immunogen sequence: HPHPICEVSK VASHLEVNCD KRNLTALPPD LPKDTTILHL SENLLYTFSL ATLMPYTRLT QLNLDRCELT KLQVDGTLPV LGTLDLSHNQ LQSLPLLGQT LPALTVLDVS FNRLTSLPLG ALRGLGELQE LYLKGNELKT LPPGLLTPTP KLEKLSLANN NLTELPAGLL NGLENLDTLL LQENSLYTIP KGFFGSHLLP FAFLHGNPWL CNCEILYFRR WLQDNAENVY VWKQGVDVKA MTSNVASVQC DNSDKFPVYK YPGKGCPTLG DEGDTDLYDY YPEEDTEGDK VRATRTVVKF PTKAHTTPWG LFYSWSTASL DSQMPSSLHP TQESTKEQTT FPPRWTPNFT LHMESITFSK TPKSTTEPTP SPTTSEPVPE PAPNMTTLEP TPSPTTPEPT SEPAPSPTTP EPTSEPAPSP TTPEPTSEPA PSPTTPEPTP IPTIATSPTI LVSATSLITP KSTFLTTTKP VSLLESTKKT IPELDQPPKL RGVLQGHLES SRNDPFLHPD FCCLLPL.

CD42b is a platelet activation marker involved in the process of coagulation as an aggregating factor. It interacts with extracellular matrix as well as with adhesion molecules. CD42b expression and activation seems to be regulated by VEGF and PDGF. CD42b composes together with GPIb beta, GPIX and GPV the GPIb-IX-V receptor complex critical in the process of platelet-rich thrombus formation by tethering the platelet to a thrombogenic surface. CD42b binds to von Willebrand factor (VWF) exposed at a site of vascular injury, as well as to thrombin, coagulation factors XI and XII, high molecular wight kininogen, TSP-1, integrin Mac-1 and P-selectin. The extracellular domain of CD42b by its interactions also contributes to metastasis. Further, CD42b antigen is expressed on platelets and on megakaryocytes in bone marrow. Several polymorphisms and mutations have been described in the CD42b, some of which are the cause of Bernard-Soulier syndromes and platelet-type von Willebrand disease.
TRUSTED_SUSTAINABILITY

Specifications

Antigen CD42b
Applications ELISA, Immunohistochemistry (Paraffin)
Classification Recombinant Monoclonal
Clone 6Y2I1
Concentration 1.01 mg/mL
Conjugate Unconjugated
Formulation PBS with 0.05% BSA, 50% glycerol and 0.09% sodium azide; pH 7.3
Gene Gp1ba
Gene Accession No. P07359
Gene Alias Antigen CD42b-alpha; BDPLT1; BDPLT3; BSS; CD42a; CD42B; CD42b-alpha; DBPLT3; Glycocalicin; glycoprotein 1b, alpha polypeptide; glycoprotein Ib (platelet), alpha polypeptide; glycoprotein Ib platelet alpha subunit; glycoprotein Ib platelet subunit alpha; glycoprotein Ibalpha; GP1B; GP1BA; GPIB; GPIb alpha; GP-Ib alpha; GPIbA; GPIbalpha; GPIX; GP-IX; MGC34595; mutant platelet membrane glycoprotein Ib-alpha; platelet glycoprotein Ib alpha chain; platelet glycoprotein Ib alpha polypeptide; Platelet GPIX; platelet membrane glycoprotein 1b-alpha subunit; platelet membrane glycoprotein Ib-alpha; VWDP
Gene Symbols Gp1ba
Host Species Rabbit
Immunogen Recombinant fusion protein containing a sequence corresponding to amino acids 15-531 of human CD42b (NP_000164.5).
Purification Method Protein A
Quantity 20 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 2811
Target Species Human
Content And Storage -20°C, Avoid Freeze/Thaw Cycles
Product Type Antibody
Form Liquid
Isotype IgG
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