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CD41 Mouse, anti-Human, APC, Clone: HIP8, STEMCELL Technologies
Mouse Monoclonal Antibody
£252.45 - £533.25
Specifications
| Antigen | CD41 |
|---|---|
| Clone | HIP8 |
| Applications | CyTOF, Flow Cytometry, Immunofluorescence, Functional Assay, Blocking Assay |
| Classification | Monoclonal |
| Conjugate | APC |
| Product Code | Brand | Quantity | Price | Quantity & Availability | |||||
|---|---|---|---|---|---|---|---|---|---|
| Product Code | Brand | Quantity | Price | Quantity & Availability | |||||
17149131
|
Stemcell Technologies
60114AZ.1 |
25 Tests |
£252.45
25 tests |
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|
17139131
|
Stemcell Technologies
60114AZ |
100 Tests |
£533.25
100 tests |
Please sign in to purchase this item. Need a web account? Register with us today! | |||||
Description
- The HIP8 antibody reacts with the ∼125 kDa GPIIbα subunit of human CD41, a heterodimeric integrin expressed primarily on platelets, megakaryocytes, monocytes, and acute megakaryoblastic leukemia cells
- The GPIIbα subunit is linked to a smaller ∼25 kDa subunit (GPIIbβ) by a single disulfide bond
- Three isoforms of CD41 that are generated by alternative splicing have been identified, one of which is expressed only by cancerous cells
- CD41 associates non-covalently with CD61 (integrin b3) in a calcium-dependent manner to form the CD41/CD61 (or GPIIb/IIIa) complex, which has been identified as a receptor for several ligands, including fibrinogen, fibronectin, vitronectin, and thrombin
- Binding to the CD41/CD61 complex involves an RGD tripeptidyl sequence in the ligand
- The HIP8 antibody reportedly blocks platelet aggregation and inhibits the activation of platelets by several compounds
Specifications
| CD41 | |
| CyTOF, Flow Cytometry, Immunofluorescence, Functional Assay, Blocking Assay | |
| APC | |
| Baboon, Cynomolgus, Pig, Human | |
| Primary |
| HIP8 | |
| Monoclonal | |
| Mouse | |
| IgG1 κ |
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