CD41 Mouse, anti-Human, APC, Clone: HIP8, STEMCELL Technologies

Mouse Monoclonal Antibody

Brand:  Stemcell Technologies 60114AZ.1

Product Code. 17149131

Description

• The HIP8 antibody reacts with the ∼125 kDa GPIIbα subunit of human CD41, a heterodimeric integrin expressed primarily on platelets, megakaryocytes, monocytes, and acute megakaryoblastic leukemia cells
• The GPIIbα subunit is linked to a smaller ∼25 kDa subunit (GPIIbβ) by a single disulfide bond
• Three isoforms of CD41 that are generated by alternative splicing have been identified, one of which is expressed only by cancerous cells
• CD41 associates non-covalently with CD61 (integrin b3) in a calcium-dependent manner to form the CD41/CD61 (or GPIIb/IIIa) complex, which has been identified as a receptor for several ligands, including fibrinogen, fibronectin, vitronectin, and thrombin
• Binding to the CD41/CD61 complex involves an RGD tripeptidyl sequence in the ligand
• The HIP8 antibody reportedly blocks platelet aggregation and inhibits the activation of platelets by several compounds

Specifications

• Antigen: CD41
• Classification: Monoclonal
• Conjugate: APC
• Quantity: 25 Tests
• Target Species: Baboon, Cynomolgus, Pig, Human
• Cell Type: Megakaryocytes, Platelets

• Applications: CyTOF, Flow Cytometry, Immunofluorescence, Functional Assay, Blocking Assay
• Clone: HIP8
• Host Species: Mouse
• Primary or Secondary: Primary
• Isotype: IgG1 κ