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CD4 Mouse, anti-Human, PE, Clone: SK3, STEMCELL Technologies
Mouse Monoclonal Antibody
£60.75 - £153.90
Specifications
| Antigen | CD4 |
|---|---|
| Clone | SK3 |
| Applications | Flow Cytometry |
| Classification | Monoclonal |
| Conjugate | PE |
| Product Code | Brand | Quantity | Price | Quantity & Availability | |||||
|---|---|---|---|---|---|---|---|---|---|
| Product Code | Brand | Quantity | Price | Quantity & Availability | |||||
17149151
|
Stemcell Technologies
60122PE.1 |
25 Tests |
£60.75
25 tests |
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|
17139151
|
Stemcell Technologies
60122PE |
100 Tests |
£153.90
100 tests |
Please sign in to purchase this item. Need a web account? Register with us today! | |||||
Description
- The SK3 antibody reacts with CD4, an ∼59 kDa single-chain type 1 transmembrane glycoprotein and member of the immunoglobulin (Ig) superfamily; CD4 contains four extracellular Ig-like domains (D1 - D4)
- The epitope for SK3 has been localized to the D3 domain of the protein, which has a structure resembling an Ig variable domain
- CD4 is expressed at relatively high levels by most thymocytes and a subpopulation of T cells (T-helper cells), and at lower levels by peripheral blood monocytes and macrophages
- CD4 binds to a non-polymorphic region of MHC II and acts as a co-receptor to the T cell receptor (TCR) in MHC II-restricted antigen recognition by enhancing the affinity of the association between the TCR and MHC II-antigen complex
- CD4 also functions to amplify signals from the TCR to the cytoplasm through the interaction of its intracellular domain with cytoplasmic tyrosine kinases such as Lck
- Binding of the SK3 antibody blocks HIV binding and mixed lymphocyte reaction (MLR)
Specifications
| CD4 | |
| Flow Cytometry | |
| PE | |
| Human | |
| Primary |
| SK3 | |
| Monoclonal | |
| Mouse | |
| IgG1 κ |
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