Invitrogen™ CD366 (TIM3) Monoclonal Antibody (8B.2C12), Functional Grade, eBioscience™, Invitrogen™

Rat Monoclonal Antibody

Product Code	Brand	Quantity
17181312	Invitrogen™ 16-5871-38	5 mg
17161312	Affymetrix eBioscience 16-5871-025	25 mg
17171312	Affymetrix eBioscience 16-5871-050	50 mg

Description

TIM3 (Hepatitis A virus cellular receptor 2, HAVCR2, T-cell immunoglobulin, mucin-dmain containing-3) is a 281 amino acid long, Type-1 Th1- specific cell surface glycoprotein expressed on terminally differentiated CD4+Th1 and CD8+Tc1 cells. TIM3 consists of an IgV-like domain, a mucin-like domain in the extracellular region, and a conserved Tyrosine phosphorylation motif in the cytoplasmic region. TIM3 is involved in macrophage activation and induction of autoimmune diseases. Further, TIM3 down-regulates aggressive Th1-mediated immune responses and facilitates in the development of immune tolerance. Pathological significance of TIM3 has been attributed to Experimental autoimmune encephalomyelitis (EAE), a Th-1 dependent autoimmune disease, and also enhances the severity of experimental autoimmune encephalomyelitis in mice.

Specifications

• Antigen: CD366 (TIM3)
• Concentration: 1 mg/mL
• Classification: Monoclonal
• Form: Liquid
• Regulatory Status: RUO
• Formulation: PBS with no preservative; pH 7.2
• Gene ID (Entrez): 171285
• Primary or Secondary: Primary
• Content And Storage: 4°C
• Gene: Havcr2

• Clone: 8B.2C12
• Applications: Flow Cytometry, Functional Assay
• Conjugate: Functional Grade
• Host Species: Rat
• Target Species: Mouse
• Gene Accession No.: Q8VIM0
• Isotype: IgG1 κ
• Purification Method: Affinity chromatography
• Product Type: Antibody