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CD32 Mouse, anti-Human, FITC, Clone: IV.3, STEMCELL Technologies
Mouse Monoclonal Antibody
POA - £207.90
Specifications
| Antigen | CD32 |
|---|---|
| Clone | IV.3 |
| Applications | Blocking Assay, Western Blot, Flow Cytometry, Immunocytochemistry, Functional Assay |
| Classification | Monoclonal |
| Conjugate | FITC |
| Product Code | Brand | Quantity | Price | Quantity & Availability | |||||
|---|---|---|---|---|---|---|---|---|---|
| Product Code | Brand | Quantity | Price | Quantity & Availability | |||||
17108431
|
Stemcell Technologies
60012FI.1 |
25 Tests |
£207.90
25 tests |
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|
17161046
|
Stemcell Technologies
60012FI |
100 Tests | |||||||
Description
- The IV.3 antibody reacts with human CD32 (FcγRII), an ∼40 kDa type 1 transmembrane glycoprotein that mediates several functions including phagocytosis, cytotoxicity, immunomodulation and platelet aggregation
- CD32 is encoded by three genes (A, B, C) and at least 6 isoforms are generated via alternative mRNA splicing, i.e., IIa1, IIa2, IIb1, IIb2, IIb3 and IIc
- All isoforms are expressed by monocytes/macrophages, placental trophoblasts and endothelial cells
- In addition, the IIb isoform is expressed by B cells, and the IIa isoform by platelets, granulocytes and, weakly, by B cells
- Isoform IIc is expressed by NK cells and neutrophils
- CD32 binds weakly to the Fc region of monomeric IgG but more strongly to IgG aggregates and immune complexes
- This antibody clone has been verified for purity assessments of cells isolated with EasySep™ kits, including EasySep™ Human T Cell Enrichment Kit (Catalog #19051) and EasySep™ Human CD4+ T Cell Enrichment Kit (Catalog #19052)
Specifications
| CD32 | |
| Blocking Assay, Western Blot, Flow Cytometry, Immunocytochemistry, Functional Assay | |
| FITC | |
| Human | |
| Primary |
| IV.3 | |
| Monoclonal | |
| Mouse | |
| IgG2b κ |
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