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  6. CD32 Mouse, anti-Human, FITC, Clone: IV.3, STEMCELL Technologies

CD32 Mouse, anti-Human, FITC, Clone: IV.3, STEMCELL Technologies

Product Code. 17108431
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100 Tests
25 Tests
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100 tests
25 tests
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17108431 25 Tests 25 tests
17161046 100 Tests 100 tests
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Product Code. 17108431 Supplier Stemcell Technologies Supplier No. 60012FI.1

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Description

Mouse Monoclonal Antibody

  • The IV.3 antibody reacts with human CD32 (FcγRII), an ∼40 kDa type 1 transmembrane glycoprotein that mediates several functions including phagocytosis, cytotoxicity, immunomodulation and platelet aggregation
  • CD32 is encoded by three genes (A, B, C) and at least 6 isoforms are generated via alternative mRNA splicing, i.e., IIa1, IIa2, IIb1, IIb2, IIb3 and IIc
  • All isoforms are expressed by monocytes/macrophages, placental trophoblasts and endothelial cells
  • In addition, the IIb isoform is expressed by B cells, and the IIa isoform by platelets, granulocytes and, weakly, by B cells
  • Isoform IIc is expressed by NK cells and neutrophils
  • CD32 binds weakly to the Fc region of monomeric IgG but more strongly to IgG aggregates and immune complexes
  • This antibody clone has been verified for purity assessments of cells isolated with EasySep™ kits, including EasySep™ Human T Cell Enrichment Kit (Catalog #19051) and EasySep™ Human CD4+ T Cell Enrichment Kit (Catalog #19052)

Specifications

Antigen CD32
Applications Blocking Assay, Western Blot, Flow Cytometry, Immunocytochemistry, Functional Assay
Classification Monoclonal
Clone IV.3
Conjugate FITC
Host Species Mouse
Quantity 25 Tests
Primary or Secondary Primary
Target Species Human
Isotype IgG2b κ
Cell Type B Cells, Granulocytes and Subsets, Monocytes
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