CD32 Mouse, anti-Human, FITC, Clone: IV.3, STEMCELL Technologies

Mouse Monoclonal Antibody

Brand:  Stemcell Technologies 60012FI.1

Product Code. 17108431

Description

• The IV.3 antibody reacts with human CD32 (FcγRII), an ∼40 kDa type 1 transmembrane glycoprotein that mediates several functions including phagocytosis, cytotoxicity, immunomodulation and platelet aggregation
• CD32 is encoded by three genes (A, B, C) and at least 6 isoforms are generated via alternative mRNA splicing, i.e., IIa1, IIa2, IIb1, IIb2, IIb3 and IIc
• All isoforms are expressed by monocytes/macrophages, placental trophoblasts and endothelial cells
• In addition, the IIb isoform is expressed by B cells, and the IIa isoform by platelets, granulocytes and, weakly, by B cells
• Isoform IIc is expressed by NK cells and neutrophils
• CD32 binds weakly to the Fc region of monomeric IgG but more strongly to IgG aggregates and immune complexes
• This antibody clone has been verified for purity assessments of cells isolated with EasySep™ kits, including EasySep™ Human T Cell Enrichment Kit (Catalog #19051) and EasySep™ Human CD4+ T Cell Enrichment Kit (Catalog #19052)

Specifications

• Antigen: CD32
• Classification: Monoclonal
• Conjugate: FITC
• Quantity: 25 Tests
• Target Species: Human
• Cell Type: B Cells, Granulocytes and Subsets, Monocytes

• Applications: Blocking Assay, Western Blot, Flow Cytometry, Immunocytochemistry, Functional Assay
• Clone: IV.3
• Host Species: Mouse
• Primary or Secondary: Primary
• Isotype: IgG2b κ