CD3 Mouse, anti-Human, FITC, Clone: SK7, STEMCELL Technologies

Mouse Monoclonal Antibody

Product Code	Brand	Quantity
17139161	Stemcell Technologies 60127FI.1	25 Tests
17129161	Stemcell Technologies 60127FI	100 Tests

Description

• The SK7 antibody reacts with the ∼20 kDa CD3ε subunit of the human T cell receptor (TCR)/CD3 complex, which is expressed on the surface of ∼95% of mature T cells and NKT cells, and variably on thymocytes
• A majority of T cell neoplasms also express CD3
• The CD3 complex, which is assembled from combinations of CD3γ, δ, ε, η and ζ subunits, associates non-covalently with the TCR and is involved in transducing antigen recognition signals into the cytoplasm of T cells and in regulating the cell surface expression of the TCR
• Activation of T cells by the TCR involves the cytoplasmic tails of the CD3 subunits, which are structurally related type 1 transmembrane proteins and members of the immunoglobulin superfamily
• Mutations in the CD3 subunits have been associated with various immunodeficiency disorders, including severe combined immunodeficiency (SCID)

Specifications

• Antigen: CD3
• Applications: Flow Cytometry
• Conjugate: FITC
• Target Species: Chimpanzee, Human
• Primary or Secondary: Primary

• Clone: SK7
• Classification: Monoclonal
• Host Species: Mouse
• Isotype: IgG1 κ