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CD267 (TACI) Rat, anti-Mouse, APC, Clone: 8F10, STEMCELL Technologies
Rat Monoclonal Antibody
£176.85 - £322.65
Specifications
| Antigen | CD267 (TACI) |
|---|---|
| Clone | 8F10 |
| Applications | Flow Cytometry |
| Classification | Monoclonal |
| Conjugate | APC |
| Product Code | Brand | Quantity | Price | Quantity & Availability | |||||
|---|---|---|---|---|---|---|---|---|---|
| Product Code | Brand | Quantity | Price | Quantity & Availability | |||||
17109141
|
Stemcell Technologies
60116AZ.1 |
50 μg |
£176.85
50µg |
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|
17199131
|
Stemcell Technologies
60116AZ |
100 μg |
£322.65
100µg |
Please sign in to purchase this item. Need a web account? Register with us today! | |||||
Description
- The 8F10 antibody reacts with mouse CD267 (transmembrane activator and CAML interactor, or TACI), an ∼30 kDa type III transmembrane protein of the TNF receptor superfamily that is expressed primarily on the surface of maturing subsets of splenic B cells, including transition type 2 (T2) and marginal zone (MZ) B cells, as well as on plasma cells and plasmablasts
- Expression of CD267 is upregulated on B cells exposed to LPS both in vitro and in vivo
- CD267 plays important roles in humoral immunity by regulating B cell survival, proliferation, and maturation through its interaction with the ligands APRIL and BAFF
- Ligand binding stimulates activation of several transcription factors, including NF-kappa-B, and has been shown to induce either proliferation or apoptosis, suggesting a dual role in the regulation of B cells
- CD267 also appears to have an essential function in immunoglobulin isotype switching and B cell differentiation in response to thymus-independent antigens
Specifications
| CD267 (TACI) | |
| Flow Cytometry | |
| APC | |
| Mouse | |
| Primary |
| 8F10 | |
| Monoclonal | |
| Rat | |
| IgG2a κ |
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