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CD267 (TACI) Rat, anti-Mouse, APC, Clone: 8F10, STEMCELL Technologies
Rat Monoclonal Antibody
Brand: Stemcell Technologies 60116AZ
This item is not returnable.
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Description
- The 8F10 antibody reacts with mouse CD267 (transmembrane activator and CAML interactor, or TACI), an ∼30 kDa type III transmembrane protein of the TNF receptor superfamily that is expressed primarily on the surface of maturing subsets of splenic B cells, including transition type 2 (T2) and marginal zone (MZ) B cells, as well as on plasma cells and plasmablasts
- Expression of CD267 is upregulated on B cells exposed to LPS both in vitro and in vivo
- CD267 plays important roles in humoral immunity by regulating B cell survival, proliferation, and maturation through its interaction with the ligands APRIL and BAFF
- Ligand binding stimulates activation of several transcription factors, including NF-kappa-B, and has been shown to induce either proliferation or apoptosis, suggesting a dual role in the regulation of B cells
- CD267 also appears to have an essential function in immunoglobulin isotype switching and B cell differentiation in response to thymus-independent antigens
Specifications
| CD267 (TACI) | |
| Monoclonal | |
| APC | |
| 100 μg | |
| Mouse | |
| B Cells |
| Flow Cytometry | |
| 8F10 | |
| Rat | |
| Primary | |
| IgG2a κ |
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