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CD25 Rat, anti-Mouse, PerCP-Cyanine5.5, Clone: PC61.5, STEMCELL Technologies
Rat Monoclonal Antibody
£205.20 - £557.55
Specifications
| Antigen | CD25 |
|---|---|
| Clone | PC61.5 |
| Applications | Immunohistochemistry, Flow Cytometry, Functional Assay, Blocking Assay |
| Classification | Monoclonal |
| Conjugate | PerCP-Cyanine5.5 |
| Product Code | Brand | Quantity | Price | Quantity & Availability | |||||
|---|---|---|---|---|---|---|---|---|---|
| Product Code | Brand | Quantity | Price | Quantity & Availability | |||||
17198401
|
Stemcell Technologies
60009PS.1 |
25 μg |
£205.20
25µg |
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|
17188401
|
Stemcell Technologies
60009PS |
100 μg |
£557.55
100µg |
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Description
- The PC61.5 antibody reacts with mouse CD25 (low-affinity interleukin‐2 receptor α chain or IL-2Rα), which is an ∼55 kDa type 1 transmembrane glycoprotein expressed on T and B cell progenitors, activated (but not resting) T and B cells, regulatory T (Treg) cells, dendritic cells, and activated monocytes and macrophages
- Expression of CD25, together with CD4 and FOXP3, is considered a phenotypic signature for Treg cells
- CD25 per se has low affinity for its IL-2 ligand but associates with CD122 (IL-2Rβ) and CD132 (IL-2Rγ) to form the high-affinity IL-2R receptor
- CD25 is necessary for receptor clustering and induction of signaling pathways involved in the activation and proliferation of lymphocytes
- Binding of the PC61.5 antibody inhibits binding of IL-2 to the low- and high-affinity receptors, which may result in inhibition of IL-2-dependent proliferation
- The epitope recognized by PC61.5 is distinct from the IL-2 binding site and from the epitopes recognized by antibodies 7D4 and 3C7
Specifications
| CD25 | |
| Immunohistochemistry, Flow Cytometry, Functional Assay, Blocking Assay | |
| PerCP-Cyanine5.5 | |
| Mouse | |
| Primary |
| PC61.5 | |
| Monoclonal | |
| Rat | |
| IgG1 λ |
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