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CD20 Mouse, anti-Human, APC, Clone: 2H7, STEMCELL Technologies
Mouse Monoclonal Antibody
£240.30 - £484.65
Specifications
| Antigen | CD20 |
|---|---|
| Clone | 2H7 |
| Applications | CyTOF, ELISA, Flow Cytometry, Immunohistochemistry, Immunoprecipitation |
| Classification | Monoclonal |
| Conjugate | APC |
| Product Code | Brand | Quantity | Price | Quantity & Availability | |||||
|---|---|---|---|---|---|---|---|---|---|
| Product Code | Brand | Quantity | Price | Quantity & Availability | |||||
17128391
|
Stemcell Technologies
60008AZ.1 |
25 Tests |
£240.30
25 tests |
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|
17118391
|
Stemcell Technologies
60008AZ |
100 Tests |
£484.65
100 tests |
Please sign in to purchase this item. Need a web account? Register with us today! | |||||
Description
- Antibody 2H7 reacts with CD20, an ∼35 kDa non-glycosylated type 1 transmembrane protein in the MS4A protein family
- The CD20 polypeptide transverses the cell membrane four times, with only a minor portion of the protein displayed on the cell surface
- The epitope recognized by antibody 2H7 has been mapped to the amino acid sequence YNCEPANPSEKNSPST, located in the large extracellular loop of CD20
- CD20 is expressed on pre-B cells, resting and activated B cells, some follicular dendritic cells, and a subset of T cells
- Expression by B cells is lost upon their differentiation into plasma cells
- By associating with several proteins, including the B cell receptor (CD79), MHC class I and II, CD53, CD81, and CD82, CD20 is involved in initiating intracellular signaling pathways that modulate the activation, proliferation, and differentiation of B cells
- It is thought that CD20 forms multi-subunit ion channels that regulate calcium ion flux across the plasma membrane
Specifications
| CD20 | |
| CyTOF, ELISA, Flow Cytometry, Immunohistochemistry, Immunoprecipitation | |
| APC | |
| Baboon, Cynomolgus, Chimpanzee, Human | |
| Primary |
| 2H7 | |
| Monoclonal | |
| Mouse | |
| IgG2b κ |
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