CD20 Mouse, anti-Human, APC, Clone: 2H7, STEMCELL Technologies

Mouse Monoclonal Antibody

Brand:  Stemcell Technologies 60008AZ.1

Product Code. 17128391

Description

• Antibody 2H7 reacts with CD20, an ∼35 kDa non-glycosylated type 1 transmembrane protein in the MS4A protein family
• The CD20 polypeptide transverses the cell membrane four times, with only a minor portion of the protein displayed on the cell surface
• The epitope recognized by antibody 2H7 has been mapped to the amino acid sequence YNCEPANPSEKNSPST, located in the large extracellular loop of CD20
• CD20 is expressed on pre-B cells, resting and activated B cells, some follicular dendritic cells, and a subset of T cells
• Expression by B cells is lost upon their differentiation into plasma cells
• By associating with several proteins, including the B cell receptor (CD79), MHC class I and II, CD53, CD81, and CD82, CD20 is involved in initiating intracellular signaling pathways that modulate the activation, proliferation, and differentiation of B cells
• It is thought that CD20 forms multi-subunit ion channels that regulate calcium ion flux across the plasma membrane

Specifications

• Antigen: CD20
• Classification: Monoclonal
• Conjugate: APC
• Quantity: 25 Tests
• Target Species: Baboon, Cynomolgus, Chimpanzee, Human
• Cell Type: B Cells

• Applications: CyTOF, ELISA, Flow Cytometry, Immunohistochemistry, Immunoprecipitation
• Clone: 2H7
• Host Species: Mouse
• Primary or Secondary: Primary
• Isotype: IgG2b κ