CD2 Mouse, anti-Human, APC, Clone: RPA-2.10, STEMCELL Technologies

Mouse Monoclonal Antibody

Brand:  Stemcell Technologies 60007AZ

Product Code. 17128381

Description

• The RPA-2.10 antibody reacts with CD2, an ∼50 kDa type I transmembrane glycoprotein and a member of the immunoglobulin (Ig) superfamily; two Ig-like domains are located in its extracellular portion
• CD2 is broadly expressed on peripheral T and NK cells, dendritic cells, erythrocytes, most thymic T cells, subsets of thymic B cells, and on the endothelium
• CD2 expression appears early during T cell differentiation
• Aberrant expression has been observed in some lymphomas and myeloid leukemias
• CD2 is critically important for T cell activation and signaling, as well as lymphocyte adhesion
• The primary ligand for CD2 is CD58 (LFA-3) located on antigen-presenting cells, with additional ligands comprising CD15 (SSEA-1), CD48 and CD59
• Notably, the RPA-2.10 antibody blocks the mixed lymphocyte reaction

Specifications

• Antigen: CD2
• Classification: Monoclonal
• Conjugate: APC
• Quantity: 100 Tests
• Target Species: Baboon, Cynomolgus, Pig, Human
• Cell Type: T Cells

• Applications: Immunohistochemistry, Western Blot, Flow Cytometry, Immunocytochemistry, Immunofluorescence
• Clone: RPA-2.10
• Host Species: Mouse
• Primary or Secondary: Primary
• Isotype: IgG1 κ