missing translation for 'onlineSavingsMsg'
Learn More
Learn More
CD184 (CXCR4) Mouse, anti-Human, PE, Clone: 12G5, STEMCELL Technologies
Mouse Monoclonal Antibody
£226.80 - £502.20
Specifications
| Antigen | CD184 (CXCR4) |
|---|---|
| Clone | 12G5 |
| Applications | CyTOF, Flow Cytometry, Immunocytochemistry, Immunofluorescence, Functional Assay |
| Classification | Monoclonal |
| Conjugate | PE |
| Product Code | Brand | Quantity | Price | Quantity & Availability | |||||
|---|---|---|---|---|---|---|---|---|---|
| Product Code | Brand | Quantity | Price | Quantity & Availability | |||||
17178961
|
Stemcell Technologies
60089PE.1 |
25 Tests |
£226.80
25 tests |
Please sign in to purchase this item. Need a web account? Register with us today! | |||||
|
17168961
|
Stemcell Technologies
60089PE |
100 Tests |
£502.20
100 tests |
Please sign in to purchase this item. Need a web account? Register with us today! | |||||
Description
- The 12G5 antibody reacts with CD184 (CXCR4 or fusin), an ∼45 kDa seven transmembrane G-protein-coupled receptor expressed on the surface of a broad range of cells, including T and B cells, dendritic cells, monocytes, macrophages, granulocytes, platelets, endothelial and epithelial cells, astrocytes and neurons
- At least two isoforms of CD184 are generated by alternate mRNA splicing
- Ligands for CD184 include the CXC chemokine SDF-1 and ubiquitin
- CD184 has functional roles in mediating chemotaxis, B cell lymphopoiesis and myelopoiesis, cardiogenesis, vascularization and neuronal guidance
- CD184 acts as a co-receptor for infection by some T cell-tropic isolates of HIV-1 and as an alternative receptor for CD4-independent infection by HIV-2; functions that are blocked by binding of the 12G5 antibody
- The antibody also partially inhibits SDF-1-induced chemotaxis and calcium influx
- CD184 is used along with other markers such as CD117 to monitor the emergence of definitive endoderm
Specifications
| CD184 (CXCR4) | |
| CyTOF, Flow Cytometry, Immunocytochemistry, Immunofluorescence, Functional Assay | |
| PE | |
| African Green Monkey, Baboon, Cynomolgus, Rhesus Monkey, Human | |
| Primary |
| 12G5 | |
| Monoclonal | |
| Mouse | |
| IgG2a κ |
Spot an opportunity for improvement?Share a Content Correction
Product Content Correction
The Fisher Scientific Encompass Program offers items which are not part of our distribution portfolio. These products typically do not have pictures or detailed descriptions. However, we are committed to improving your shopping experience. Please use the form below to provide feedback related to the content on this product.
Product Title