CD184 (CXCR4) Mouse, anti-Human, PE, Clone: 12G5, STEMCELL Technologies

Mouse Monoclonal Antibody

Brand:  Stemcell Technologies 60089PE

Product Code. 17168961

Description

• The 12G5 antibody reacts with CD184 (CXCR4 or fusin), an ∼45 kDa seven transmembrane G-protein-coupled receptor expressed on the surface of a broad range of cells, including T and B cells, dendritic cells, monocytes, macrophages, granulocytes, platelets, endothelial and epithelial cells, astrocytes and neurons
• At least two isoforms of CD184 are generated by alternate mRNA splicing
• Ligands for CD184 include the CXC chemokine SDF-1 and ubiquitin
• CD184 has functional roles in mediating chemotaxis, B cell lymphopoiesis and myelopoiesis, cardiogenesis, vascularization and neuronal guidance
• CD184 acts as a co-receptor for infection by some T cell-tropic isolates of HIV-1 and as an alternative receptor for CD4-independent infection by HIV-2; functions that are blocked by binding of the 12G5 antibody
• The antibody also partially inhibits SDF-1-induced chemotaxis and calcium influx
• CD184 is used along with other markers such as CD117 to monitor the emergence of definitive endoderm

Specifications

• Antigen: CD184 (CXCR4)
• Classification: Monoclonal
• Conjugate: PE
• Quantity: 100 Tests
• Target Species: African Green Monkey, Baboon, Cynomolgus, Rhesus Monkey, Human
• Cell Type: Endoderm, PSC-Derived, Pluripotent Stem Cells

• Applications: CyTOF, Flow Cytometry, Immunocytochemistry, Immunofluorescence, Functional Assay
• Clone: 12G5
• Host Species: Mouse
• Primary or Secondary: Primary
• Isotype: IgG2a κ