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CD117 (c-Kit) Rat, anti-Mouse, FITC, Clone: 2B8, STEMCELL Technologies
Rat Monoclonal Antibody
POA
Specifications
| Antigen | CD117 (c-Kit) |
|---|---|
| Clone | 2B8 |
| Applications | Immunohistochemistry, Flow Cytometry, Immunocytochemistry, Immunofluorescence, Immunoprecipitation |
| Classification | Monoclonal |
| Conjugate | FITC |
Description
- The 2B8 antibody reacts with CD117 (c-Kit), an ∼145 kDa type 1 transmembrane receptor for c-Kit ligand (stem cell factor/steel factor) that is broadly expressed on hematopoietic stem cells in bone marrow, including pluripotent and erythroid progenitor cells and B and T lymphocyte precursors, as well as on mast cells
- CD117 belongs to the tyrosine kinase receptor family and possesses five immunoglobulin-like C2-type domains and a cytoplasmic protein kinase domain
- Binding of c-Kit ligand to CD117 induces dimerization and autophosphorylation, which activates several intracellular signaling pathways critical for the proliferation and differentiation of hematopoietic stem cells
- The 2B8 antibody does not block binding of c-Kit ligand
- This antibody clone has been verified for purity assessments of cells isolated with EasySep™ kits, including EasySep™ Mouse Hematopoietic Progenitor Cell Isolation Kit (Catalog #19856)
Specifications
| CD117 (c-Kit) | |
| Immunohistochemistry, Flow Cytometry, Immunocytochemistry, Immunofluorescence, Immunoprecipitation | |
| FITC | |
| Mouse | |
| Primary |
| 2B8 | |
| Monoclonal | |
| Rat | |
| IgG2b κ |
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