CD117 (c-Kit) Rat, anti-Mouse, FITC, Clone: 2B8, STEMCELL Technologies

Rat Monoclonal Antibody

Brand:  Stemcell Technologies 60025FI

Product Code. 17108581

Description

• The 2B8 antibody reacts with CD117 (c-Kit), an ∼145 kDa type 1 transmembrane receptor for c-Kit ligand (stem cell factor/steel factor) that is broadly expressed on hematopoietic stem cells in bone marrow, including pluripotent and erythroid progenitor cells and B and T lymphocyte precursors, as well as on mast cells
• CD117 belongs to the tyrosine kinase receptor family and possesses five immunoglobulin-like C2-type domains and a cytoplasmic protein kinase domain
• Binding of c-Kit ligand to CD117 induces dimerization and autophosphorylation, which activates several intracellular signaling pathways critical for the proliferation and differentiation of hematopoietic stem cells
• The 2B8 antibody does not block binding of c-Kit ligand
• This antibody clone has been verified for purity assessments of cells isolated with EasySep™ kits, including EasySep™ Mouse Hematopoietic Progenitor Cell Isolation Kit (Catalog #19856)

Specifications

• Antigen: CD117 (c-Kit)
• Classification: Monoclonal
• Conjugate: FITC
• Quantity: 500 μg
• Target Species: Mouse
• Cell Type: Hematopoietic Stem and Progenitor Cells

• Applications: Immunohistochemistry, Flow Cytometry, Immunocytochemistry, Immunofluorescence, Immunoprecipitation
• Clone: 2B8
• Host Species: Rat
• Primary or Secondary: Primary
• Isotype: IgG2b κ