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CD117 (c-Kit) Mouse, anti-Human, Unconjugated, Clone: 104D2, STEMCELL Technologies
Mouse Monoclonal Antibody
£124.20 - £301.05
Specifications
| Antigen | CD117 (c-Kit) |
|---|---|
| Clone | 104D2 |
| Applications | CyTOF, Flow Cytometry, Immunocytochemistry, Immunofluorescence, Immunohistochemistry |
| Classification | Monoclonal |
| Conjugate | Unconjugated |
| Product Code | Brand | Quantity | Price | Quantity & Availability | |||||
|---|---|---|---|---|---|---|---|---|---|
| Product Code | Brand | Quantity | Price | Quantity & Availability | |||||
17168951
|
Stemcell Technologies
60087.1 |
25 μg |
£124.20
25µg |
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|
17158951
|
Stemcell Technologies
60087 |
100 μg |
£301.05
100µg |
Please sign in to purchase this item. Need a web account? Register with us today! | |||||
Description
- The 104D2 antibody reacts with CD117 (c-Kit), an ∼145 kDa type 1 transmembrane receptor for c-Kit ligand (stem cell factor/steel factor) that is broadly expressed on hematopoietic stem cells in bone marrow, including pluripotent and erythroid progenitor cells and B and T lymphocyte precursors, as well as on mast cells and melanocytes
- CD117 is expressed on ∼1 - 4% of bone marrow cells, the majority of which (∼50 - 70%) co-express CD34 and comprise progenitor cells and their precursors
- CD117 belongs to the tyrosine kinase receptor family and possesses five immunoglobulin-like C2-type domains and a cytoplasmic protein kinase domain
- Binding of c-Kit ligand to CD117 induces dimerization and autophosphorylation, which activates several intracellular signaling pathways critical for the proliferation and differentiation of hematopoietic stem cells
- Binding of the 104D2 antibody does not block binding of c-Kit ligand or antibody clone SR1
Specifications
| CD117 (c-Kit) | |
| CyTOF, Flow Cytometry, Immunocytochemistry, Immunofluorescence, Immunohistochemistry | |
| Unconjugated | |
| Cynomolgus, Human | |
| Primary |
| 104D2 | |
| Monoclonal | |
| Mouse | |
| IgG1 κ |
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