CD117 (c-Kit) Mouse, anti-Human, Unconjugated, Clone: 104D2, STEMCELL Technologies

Mouse Monoclonal Antibody

Brand:  Stemcell Technologies 60087.1

Product Code. 17168951

Description

• The 104D2 antibody reacts with CD117 (c-Kit), an ∼145 kDa type 1 transmembrane receptor for c-Kit ligand (stem cell factor/steel factor) that is broadly expressed on hematopoietic stem cells in bone marrow, including pluripotent and erythroid progenitor cells and B and T lymphocyte precursors, as well as on mast cells and melanocytes
• CD117 is expressed on ∼1 - 4% of bone marrow cells, the majority of which (∼50 - 70%) co-express CD34 and comprise progenitor cells and their precursors
• CD117 belongs to the tyrosine kinase receptor family and possesses five immunoglobulin-like C2-type domains and a cytoplasmic protein kinase domain
• Binding of c-Kit ligand to CD117 induces dimerization and autophosphorylation, which activates several intracellular signaling pathways critical for the proliferation and differentiation of hematopoietic stem cells
• Binding of the 104D2 antibody does not block binding of c-Kit ligand or antibody clone SR1

Specifications

• Antigen: CD117 (c-Kit)
• Classification: Monoclonal
• Conjugate: Unconjugated
• Quantity: 25 μg
• Target Species: Cynomolgus, Human
• Cell Type: Endoderm, PSC-Derived, Hematopoietic Stem and Progenitor Cells

• Applications: CyTOF, Flow Cytometry, Immunocytochemistry, Immunofluorescence, Immunohistochemistry
• Clone: 104D2
• Host Species: Mouse
• Primary or Secondary: Primary
• Isotype: IgG1 κ