Carboxypeptidase A6 Rabbit anti-Human, Mouse, Rat, Polyclonal, Proteintech

Rabbit Polyclonal Antibody

Product Code	Brand	Quantity
16801904	Proteintech 13604-1-AP-20UL	20 μL
16891894	Proteintech 13604-1-AP-150UL	150 μL

Description

Members of the M14 metallocarboxypeptidase protein family serve many diverse functions and are divided into three subfamilies based on structure, function and amino acid sequence similarity. As a member of the A/B subfamily, CPA6 (Carboxypeptidase A6) is a 437 amino acid secreted, zinc-binding protein that contains a characteristic propetide at the amino terminus,which is cleaved off upon enzyme activation. Although expressed broadly in embryonic tissues, CPA6 is found at highest levels in the adult olfactory bulb and epididymus. CPA6 functions to cleave large C-terminal hydrophobic residues off of proteins and protein substrates and is likely involved in the extracellular processing of neuropeptides. Mutations in the gene encoding CPA6 have been linked to Duane syndrome, a congential eye-movement disorder characterized by the abnormal development of cranial nerve VI (the abducens nerve). There are three isoforms of CPA6 that exist as a result of alternative splicing events.

Specifications

• Antigen: Carboxypeptidase A6
• Applications: Immunofluorescence, Immunocytochemistry, Western Blot, Immunohistochemistry (Paraffin)
• Conjugate: Unconjugated
• Host Species: Rabbit
• Target Species: Rat, Human, Mouse
• Gene Accession No.: Q5U901, Q8N4T0
• Gene ID (Entrez): 312913, 329093, 57094
• Immunogen: Carboxypeptidase A6 Fusion Protein Ag4466
• Primary or Secondary: Primary
• Content And Storage: -20°C
• Gene: CPA6

• Concentration: 0.13 mg/mL
• Classification: Polyclonal
• Form: Liquid
• Regulatory Status: RUO
• Formulation: PBS with 50% glycerol and 0.02% sodium azide; pH 7.3
• Gene Alias: Carboxypeptidase A6, Carboxypeptidase B, CPA6, CPAH
• Gene Symbols: Cpa6
• Isotype: IgG
• Purification Method: Antigen Affinity Chromatography
• Product Type: Antibody