Carbenoxolone disodium salt, 97+%

Product Code.	Quantity	unitSize
15475899	1 g	1g
15485899	5 g	5g

Product Code. 15475899 Supplier Thermo Scientific Alfa Aesar Supplier No. J63714.03

Description

CAS: 7421-40-1 | C34H48Na2O7 | 614.73 g/mol

Carbenoxolone is anti-inflammatory. It is often used as a gap junction inhibitor in neuroscience research. Carbenoxolone is also an inhibitor of the steroid dehydrogenase enzymes 11 β-hydroxysteroid dehydrogenase (human) and 3α, 20 β-hydroxysteroid dehydrogenase (bacterial). It is used for the treatment of digestive tract ulcers, especially in the stomach. Used in the treatment of peptic, mainly gastric, ulcers. It is often used as a gap junction inhibitor in neuroscience research.

This Thermo Scientific Chemicals brand product was originally part of the Alfa Aesar product portfolio. Some documentation and label information may refer to the legacy brand. The original Alfa Aesar product / item code or SKU reference has not changed as a part of the brand transition to Thermo Scientific Chemicals.

Solubility
Soluble in water to 100 mM.

Notes
Store in cool place. Keep container tightly closed in a dry and well-ventilated place. Store away from heat.

Specifications

Chemical Identifiers

• CAS: 7421-40-1
• Molecular Formula: C34H48Na2O7
• Molecular Weight (g/mol): 614.73
• MDL Number: MFCD00079043
• InChI Key: BQENDLAVTKRQMS-SBBGFIFASA-L
• Synonym: carbenoxolone disodium salt, disodium 3beta-3-3-carboxylatopropanoyl oxy-11-oxoolean-12-en-30-oate, disodium 4as,6as,6br,10s,12as,12br,14br-10-3-carboxylatopropanoyl oxy-2,4a,6a,6b,9,9,12a-heptamethyl-13-oxo-3,4,5,6,7,8,8a,10,11,12,12b,14b-dodecahydro-1h-picene-2-carboxylate
• PubChem CID: 133687779
• IUPAC Name: disodium;(2R,4aR,6aS,6aR,6bS,8aS,10R,12aR,14bS)-10-(3-carboxylatopropanoyloxy)-2,4a,6a,6b,9,9,12a-heptamethyl-13-oxo-3,4,5,6,6a,7,8,8a,10,11,12,14b-dodecahydro-1H-picene-2-carboxylate
• SMILES: [Na+].[Na+].[H][C@@]12C[C@](C)(CC[C@]1(C)CC[C@]1(C)C2=CC(=O)[C@]2([H])[C@@]3(C)CC[C@H](OC(=O)CCC([O-])=O)C(C)(C)[C@]3([H])CC[C@@]12C)C([O-])=O

• Color: White to Cream
• Quantity: 1 g
• Merck Index: 14,1793
• Solubility Information: Soluble in water to 100 mM.
• Formula Weight: 614.7
• Percent Purity: ≥97%
• Physical Form: Solid
• Chemical Name or Material: Carbenoxolone disodium salt

Safety and Handling

Product Identifier

• Carbenoxolone disodium salt

Signal Word

• Warning

Hazard Category

• Serious eye damage/eye irritation Category 2
• Skin corrosion/irritation Category 2
• Specific target organ toxicity Category 3

Hazard Statement

• H315-Causes skin irritation.
• H319-Causes serious eye irritation.
• H335-May cause respiratory irritation.

Precautionary Statement

• P280-Wear protective gloves/protective clothing/eye protection/face protection.
• P302+P352-IF ON SKIN: Wash with plenty of water/soap.
• P304+P340-IF INHALED: Remove person to fresh air and keep comfortable for breathing.
• P312-Call a POISON CENTER/doctor/if you feel unwell.
• P332+P313-If skin irritation occurs: Get medical advice/attention.
• P337+P313-If eye irritation persists: Get medical advice/attention.

Supplemental information

• MIXTURE LIST-Contain: Carbenoxolone disodium

SDS

RUO – Research Use Only