Invitrogen™ CALM Recombinant Rabbit Monoclonal Antibody (24GB1620)

Rabbit Recombinant Monoclonal Antibody

Product Code	Brand	Quantity
30275741	Invitrogen™ MA557602	100 μL
30276249	Invitrogen™ MA557603	20 μL

Description

CALM Recombinant Monoclonal Antibody for Western Blot, Flow

PICALM, also known as the clathrin assembly lymphoid myeloid leukemia (CALM) protein, co-localizes with clathrin at clathrin-coated areas of the plasma membrane and in the Golgi area, and is thought to be an important component of the coated pit internalization machinery. Fusion proteins involving PICALM have been implicated in acute myeloid and T-cell acute lymphoblastic leukemia. PICALM is also expressed in neurons and is present at the synapse where it facilitates the endocytosis of the synaptic vesicle protein VAMP2. Recent studies have identified variants of PICALM associated with Alzheimer's disease and have suggested this protein may play a role in the endocytosis and recycling of the amyloid protein precursor (APP).

Specifications

• Antigen: CALM
• Concentration: 0.7 mg/mL
• Applications: Flow Cytometry, Western Blot, Immunocytochemistry
• Conjugate: Unconjugated
• Host Species: Rabbit
• Regulatory Status: RUO
• Formulation: PBS with 50% glycerol and 0.02% sodium azide; pH 7.4
• Gene Accession No.: Q13492
• Gene ID (Entrez): 8301
• Immunogen: A synthesized peptide derived from human PICALM (aa 550-600).
• Product Type: Antibody

• Clone: 24GB1620
• Content And Storage: -20°C
• Classification: Recombinant Monoclonal
• Form: Liquid
• Isotype: IgG
• Target Species: Human
• Gene: Picalm
• Gene Alias: CALM; Clathrin assembly lymphoid myeloid leukemia; clathrin assembly lymphoid myeloid leukemia protein; clathrin-assembly lymphoid leukemia protein; clathrin-assembly lymphoid myeloid leukemia protein; CLTH; fit1; fit-1; LAP; mKIAA4114; PAP180; phosphatidylinositol binding clathrin assembly protein; phosphatidylinositol-binding clathrin assembly protein; PICALM; rCALM
• Gene Symbols: Picalm
• Primary or Secondary: Primary
• Purification Method: Affinity chromatography