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BRL 54443, Tocris Bioscience™
Potent 5-ht1E and 5-HT1F agonist
Chemical Identifiers
| CAS | 57477-39-1 |
|---|---|
| Molecular Formula | C14H18N2O |
| Molecular Weight (g/mol) | 230.31 |
| MDL Number | MFCD01861184 |
| InChI Key | WKNFADCGOAHBPG-UHFFFAOYSA-N |
| Synonym | 3-1-methylpiperidin-4-yl-1h-indol-5-ol, unii-q2dh1chi0y, q2dh1chi0y, 1h-indol-5-ol, 3-1-methyl-4-piperidinyl, 5-hydroxy-3-1-methylpiperidin-4-yl-1h-indole, 3-1-methyl-4-piperidinyl-1h-indol-5-ol, tocris-1129, lopac-b-173, biomol-nt_000107, d0q5sl |
| PubChem CID | 2438 |
| IUPAC Name | 3-(1-methylpiperidin-4-yl)-1H-indol-5-ol |
| SMILES | CN1CCC(CC1)C1=CNC2=CC=C(O)C=C12 |
Description
A potent 5-ht1E/1F receptor agonist (pEC50 values are 8.5 and 8.6 respectively). Displays > 30-fold selectivity over other 5-HT and dopamine receptors (pKi values are 8.7. 8.9, 7.2, 6.9, 7.2, 5.9, 7.0, 6.5, < 6, < 6, 6.3 and 6.2 for human 5-HT1E, 1F, 1A, 1B, 1D, 2A, 2B, 2C, 4, 7, D2 and D3 receptors respectively). Induces 5-HT2A receptor-mediated mouse aortic contraction in vitro (pEC50 = 6.52). Active in vivo.Chemical Identifiers
| 57477-39-1 | |
| 230.31 | |
| WKNFADCGOAHBPG-UHFFFAOYSA-N | |
| 2438 | |
| CN1CCC(CC1)C1=CNC2=CC=C(O)C=C12 |
| C14H18N2O | |
| MFCD01861184 | |
| 3-1-methylpiperidin-4-yl-1h-indol-5-ol, unii-q2dh1chi0y, q2dh1chi0y, 1h-indol-5-ol, 3-1-methyl-4-piperidinyl, 5-hydroxy-3-1-methylpiperidin-4-yl-1h-indole, 3-1-methyl-4-piperidinyl-1h-indol-5-ol, tocris-1129, lopac-b-173, biomol-nt_000107, d0q5sl | |
| 3-(1-methylpiperidin-4-yl)-1H-indol-5-ol |
Specifications
| 57477-39-1 | |
| MFCD01861184 | |
| WKNFADCGOAHBPG-UHFFFAOYSA-N | |
| 3-(1-methylpiperidin-4-yl)-1H-indol-5-ol | |
| 2438 | |
| >98% |
| C14H18N2O | |
| 3-1-methylpiperidin-4-yl-1h-indol-5-ol, unii-q2dh1chi0y, q2dh1chi0y, 1h-indol-5-ol, 3-1-methyl-4-piperidinyl, 5-hydroxy-3-1-methylpiperidin-4-yl-1h-indole, 3-1-methyl-4-piperidinyl-1h-indol-5-ol, tocris-1129, lopac-b-173, biomol-nt_000107, d0q5sl | |
| CN1CCC(CC1)C1=CNC2=CC=C(O)C=C12 | |
| 230.31 | |
| 230.31 | |
| BRL 54443 |
Safety and Handling
Recommended Storage : Desiccate at +4°C
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