BRE Mouse anti-Human, Mouse, Rat, Clone: 2E5A5, Proteintech

Mouse Monoclonal Antibody

Product Code	Brand	Quantity
16868155	Proteintech 66356-1-IG-20UL	20 μL
16858155	Proteintech 66356-1-IG-150UL	150 μL

Description

BRCC45 was initially suggested to be a housekeeping protein that is highly expressed in brain and reproductive organs. Later experiments indicated BRCC45 forms a complex with the breast and ovarian predisposition proteins BRCA1 and BRCA2 as well as RAD51 and BRCC36. This complex has a ubiquitin E3 ligase activity and is thought to enhance cellular survival following DNA damage. BRCC45 has also been suggested to function as a death receptor-associated anti-apoptotic protein by inhibiting the BID-induced activation of the mitochondrial apoptotic pathway. Higher levels of BRCC45 were detected in the majority of hepatocellular carcinomas, suggesting that BRCC45 may promote tumorigenesis when overexpressed. At least three isoforms of BRCC45 are known to exist.

Specifications

• Antigen: BRE
• Concentration: 1 mg/mL
• Classification: Monoclonal
• Form: Liquid
• Regulatory Status: RUO
• Formulation: PBS with 50% glycerol and 0.02% sodium azide; pH 7.3
• Gene Alias: BRCA1 A complex subunit BRE, BRCC4, BRCC45, BRE
• Gene Symbols: Babam2
• Isotype: IgG2a
• Purification Method: Protein A
• Product Type: Antibody

• Clone: 2E5A5
• Applications: Immunocytochemistry, Western Blot, Immunohistochemistry (Paraffin), Immunofluorescence
• Conjugate: Unconjugated
• Host Species: Mouse
• Target Species: Rat, Human, Mouse
• Gene Accession No.: Q6P7Q1, Q8K3W0, Q9NXR7
• Gene ID (Entrez): 107976, 362704, 9577
• Immunogen: BRE Fusion Protein Ag2256
• Primary or Secondary: Primary
• Content And Storage: -20°C
• Gene: BABAM2