Invitrogen™ APAF1 Polyclonal Antibody, Invitrogen™

Rabbit Polyclonal Antibody

Product Code	Brand	Quantity
17930813	Invitrogen™ PA5145498	20 μL
17900073	Invitrogen™ PA5145497	200 μL

Description

APAF1 gene encodes a cytoplasmic protein that initiates apoptosis. This protein contains several copies of the WD-40 domain, a caspase recruitment domain (CARD), and an ATPase domain (NB-ARC). Upon binding cytochrome c and dATP, this protein forms an oligomeric apoptosome. The apoptosome binds and cleaves caspase 9 preproprotein, releasing its mature, activated form. Activated caspase 9 stimulates the subsequent caspase cascade that commits the cell to apoptosis. Alternative splicing results in several transcript variants encoding different isoforms.

Specifications

• Antigen: APAF1
• Applications: Immunohistochemistry (Paraffin), Western Blot, Immunocytochemistry
• Conjugate: Unconjugated
• Host Species: Rabbit
• Target Species: Mouse, Rat
• Gene Accession No.: O88879, Q9EPV5
• Gene ID (Entrez): 11783, 78963
• Immunogen: Recombinant Mouse APAF1 protein, Arg872-Phe1135 (Accession #O88879).
• Primary or Secondary: Primary
• Content And Storage: Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.

• Concentration: 0.5 mg/mL
• Classification: Polyclonal
• Form: Liquid
• Regulatory Status: RUO
• Formulation: PBS with 50% glycerol and 0.05% Proclin 300; pH 7.4
• Gene Alias: 6230400I06Rik; APAF1; APAF-1; Apaf1l; apoptotic peptidase activating factor 1; apoptotic protease activating factor 1; apoptotic protease-activating factor 1; CED4; DKFZp781B1145; fog; forebrain overgrowth; KIAA0413; mKIAA0413
• Gene Symbols: APAF1
• Isotype: IgG
• Purification Method: Antigen affinity chromatography, Protein A
• Gene: APAF1