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Ras Mouse, Unlabeled, Clone: 18, BD

Mouse Monoclonal Antibody

£172.47 - £312.74

Specifications

Antigen Ras
Isotype IgG1, κ
Immunogen Human Ras (Ha-ras) aa. 1-190
Formulation Aqueous buffered solution containing BSA, glycerol, and ≤0.09% sodium azide.
Conjugate Unconjugated
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Products 2
Product Code Brand Quantity Price Quantity & Availability  
Product Code Brand Quantity Price Quantity & Availability  
10074553
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BD Biosciences
610001
50μg
£172.47
Each
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Estimated Shipment
06-11-2020
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15825209
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BD Biosciences
610002
150μg
£312.74
1 set
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Estimated Shipment
13-11-2020
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Description

Description

Ras and related proteins of the Ras superfamily play critical roles in the control of normal and neoplastic proliferation. In mammalian cells there are four true Ras proteins (encoded by Ha- ras , N- ras , Ki- ras A, and Ki- ras B ) which, upon mutational activation, can function as independent oncogenes. These proteins relay signals from tyrosine kinases at the plasma membrane which subsequently lead to the nucleus via a network of serine/threonine kinases . The p21ras protein is active in its GTP-bound state. This form is slowly converted to the GDP-bound form by the intrinsic GTPase activity of Ras. This activity is greatly enhanced byGTPase-activating proteins (GAPs) which subsequently lead to removal of the GTP molecule and replacement with GDP. Maintenance of Ras in the GTP form can lead to transformation. One class of Ras mutations, commonly found in human tumors, results in an accumulation of Ras-GTP. The mutant Ras can bind GAP, but GAP bound in this manner seems unable to affect the Ras-GTPase activity.
Specifications

Specifications

Ras
Human Ras (Ha-ras) aa. 1-190
Unconjugated
Cell Biology
Murine
Affinity Purified
Monoclonal
Store undiluted at -20°C.
IgG1, κ
Aqueous buffered solution containing BSA, glycerol, and ≤0.09% sodium azide.
Primary
Western Blot
RUO
18
250μg/mL
SDS

For Research Use Only.