Pax-5 Mouse, Unlabeled, Clone: 24, BD

Mouse Monoclonal Antibody

Product Code	Brand	Quantity
15835679	BD Biosciences 610862	50 μg
15845679	BD Biosciences 610863	150 μg

Description

There are at least nine members of the paired box (Pax) gene family whose protein products are transcription factors involved in development. The conserved paired box DNA-binding domain is found in the N-terminal region of Pax proteins. An octomer and homeodomain sequence are conserved in the center of the proteins. The Ser/Thr/Pro-rich region in the C-terminal portion contains a conserved 100 amino acid transactivating domain. One of the best studied Pax family members, Pax 5, is a B cell specific activator protein (BSAP). In the early stages of B cell development, Pax-5 influences the expression of several B-cell-specific genes, such as CD19 and CD20. Pax-5 is expressed primarily in pro-, pre-, and mature B cells, but not in plasma cells. Interestingly, Pax-5 mRNA is transiently detected in the mesencephalon and spinal cord during embryogenesis. Expression then shifts to the fetal liver and correlates with the onset of B lymphopoiesis. Pax-5 has been found to be important in both B cell and nervous system development.

Immunofluorescence, Immunoprecipitation, Western Blotting

Specifications

• Antigen: Pax-5
• Concentration: 250μg/mL
• Classification: Monoclonal
• Host Species: Mouse
• Research Discipline: Cell Biology
• Formulation: Aqueous buffered solution containing BSA, glycerol, and ≤0.09% sodium azide.
• Isotype: IgG1
• Purification Method: Affinity Purified

• Clone: 24
• Applications: Western Blot
• Conjugate: Unconjugated
• Regulatory Status: RUO
• Target Species: Human, Mouse
• Immunogen: Human Pax-5 aa. 151-306
• Primary or Secondary: Primary
• Content And Storage: Store undiluted at -20°C.

For Research Use Only.