FAK Mouse, Unlabeled, Clone: 77/FAK, BD

Mouse Monoclonal Antibody

Product Code	Brand	Quantity
15865249	BD Biosciences 610087	50 μg
15875249	BD Biosciences 610088	150 μg

Description

Focal Adhesion Kinase (FAK) is a cytoplasmic tyrosine kinase that colocalizes with integrins in focal adhesions. This cellular localization is directed by a 125 amino acid sequence at the C-terminus called the “Focal Adhesion Targeting sequence” (FAT). The binding of extracellular matrix ligands to integrins triggers autophosphorylation and activation of FAK. This creates binding sites for SH2 domains of intracellular signaling molecules such as src, PI3 kinase, and Grb2. FAK's ability to bind numerous structural and signaling proteins via a variety of interactions has led to substantial speculation about its function. Although FAK's precise role has not been elucidated, proposed possibilities include regulating cell motility, cell growth, cytoskeletal organization, and adhesion-dependent cell survival.

Host Species: Mouse
Clone: 77
Isotype: IgG1
Species Reactivity: Human
Immunogen: Chicken FAK aa. 354-533
Formula Weight [Chemical]: 116-125kDa

Bioimaging, Immunofluorescence, Immunohistochemistry, Immunoprecipitation, Western Blotting

Specifications

• Antigen: FAK
• Concentration: 250μg/mL
• Classification: Monoclonal
• Host Species: Mouse
• Research Discipline: Cell Biology
• Formulation: Aqueous buffered solution containing BSA, glycerol, and ≤0.09% sodium azide.
• Isotype: IgG1
• Purification Method: Affinity Purified
• Description: Focal Adhesion Kinase

• Clone: 77/FAK
• Applications: Western Blot
• Conjugate: Unconjugated
• Regulatory Status: RUO
• Target Species: Canine, Chicken, Human, Mouse, Rat
• Immunogen: Chicken FAK aa. 354-533
• Primary or Secondary: Primary
• Content And Storage: Store undiluted at -20°C.

For Research Use Only.